4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide

Base Information

Chemical Name:4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide
CAS No.:61299-42-1
Molecular Formula:C₂₉H₃₁ClN₂O
Molecular Weight:459.031
Hs Code.:
European Community (EC) Number:641-536-0
UNII:5B9HO1M7AY
DSSTox Substance ID:DTXSID60210188
Wikidata:Q27261787
Mol file:61299-42-1.mol

Synonyms:Dehydro Loperamide;61299-42-1;4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide;4-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethyl-2,2-diphenylbutanamide;5B9HO1M7AY;4-[4-(4-chlorophenyl)-3,6-dihydro-2H-pyridin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;UNII-5B9HO1M7AY;Loperamide Hydrochloride Imp. H (EP);Loperamide Imp. H (EP);Loperamide Hydrochloride Impurity H;Loperamide Impurity H;Loperamide hydrochloride specified impurity H [EP];DTXSID60210188;MFCD16294895;1(2H)-Pyridinebutanamide, 4-(4-chlorophenyl)-3,6-dihydro-N,N-dimethyl-alpha,alpha-diphenyl-;BS-46305;E75274;Q27261787;LOPERAMIDE HYDROCHLORIDE IMPURITY H [EP IMPURITY];LOPERAMIDE OXIDE MONOHYDRATE IMPURITY C [EP IMPURITY];4-(4-Chlorophenyl)-3,6-dihydro-N,N-dimethyl-a,a-diphenyl-1(2H)-pyridinebutanamide;1(2H)-PYRIDINEBUTANAMIDE, 4-(4-CHLOROPHENYL)-3,6-DIHYDRO-N,N-DIMETHYL-.ALPHA.,.ALPHA.-DIPHENYL-

Suppliers and Price of 4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DehydroLoperamide
5mg
$ 120.00

Biosynth Carbosynth
Dehydro loperamide
25 mg
$ 600.00

Biosynth Carbosynth
Dehydro loperamide
10 mg
$ 280.00

Biosynth Carbosynth
Dehydro loperamide
5 mg
$ 190.00

Biosynth Carbosynth
Dehydro loperamide
2 mg
$ 100.00

Biosynth Carbosynth
Dehydro loperamide
1 mg
$ 65.00

Total 12 raw suppliers

Chemical Property of 4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide

Chemical Property:

Melting Point:127-128°C
PSA：23.55000
LogP:5.83160
Storage Temp.:Refrigerator
XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:458.2124913
Heavy Atom Count:33
Complexity:637

Purity/Quality:

98%Min ^*data from raw suppliers

DehydroLoperamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C(=O)C(CCN1CCC(=CC1)C2=CC=C(C=C2)Cl)(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide

There total 3 articles about 4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 37743-18-3
N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide

: 51304-61-1
4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride

: 61299-42-1
4-(4-(4-chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide

Guidance literature:: With sodium carbonate; In acetonitrile; at 80 ℃; for 4h;
DOI:10.1039/c6ob01248e

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 61299-42-1
4-(4-(4-chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 3 h / 0 °C

2.1: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / Reflux

3.1: hydrogenchloride / ethyl acetate / 1 h / 20 °C

4.1: sodium carbonate / acetonitrile / 4 h / 80 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; sodium hydrogencarbonate; sodium carbonate; diisopropylamine; In tetrahydrofuran; hexane; ethyl acetate; acetonitrile;
DOI:10.1039/c6ob01248e

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 61299-42-1
4-(4-(4-chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 2 h / Reflux

2: hydrogenchloride / ethyl acetate / 1 h / 20 °C

3: sodium carbonate / acetonitrile / 4 h / 80 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1039/c6ob01248e