S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

Base Information

• Chemical Name: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride
• CAS No.: 86867-01-8
• Molecular Formula: C₁₅H₂₃N₆O₅S*2ClH*Cl
• Molecular Weight: 507.826
• Mol file: 86867-01-8.mol

Synonyms:S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride;SAM chloride dihydrochloride;5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine chloride dihydrochloride;S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

Chemical Property of S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

Chemical Property:

• PSA: 207.93000
• LogP: -2.03270
• Storage Temp.: ?20°C
• Solubility.: H2O: soluble100mg/mL

Purity/Quality:

97% ^*data from raw suppliers

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride ≥75% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 6560002
• Hazard Codes: Xn
• Statements: 20/21/22-68/20/21/22
• Safety Statements: 36-45

MSDS Files:

SDS file from LookChem

Useful:

• Description: S-(5''-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine . SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine. Cayman Chemical’s SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.
• Uses: S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.