1H-INDENE,2-(2-BROMOETHYL)-2,3-DIHYDRO

Base Information

• Chemical Name: 1H-INDENE,2-(2-BROMOETHYL)-2,3-DIHYDRO
• CAS No.: 159011-42-4
• Molecular Formula: C₁₁H₁₃Br
• Molecular Weight: 225.128
• Mol file: 159011-42-4.mol

Synonyms:1H-INDENE,2-(2-BROMOETHYL)-2,3-DIHYDRO

Chemical Property of 1H-INDENE,2-(2-BROMOETHYL)-2,3-DIHYDRO

Chemical Property:

• PSA: 0.00000
• LogP: 3.18640

Purity/Quality:

1H-INDENE,2-(2-BROMOETHYL)-2,3-DIHYDRO 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDENE,2-(2-BROMOETHYL)-2,3-DIHYDRO

There total 5 articles about 1H-INDENE,2-(2-BROMOETHYL)-2,3-DIHYDRO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(indan-2-yl)ethanol (772-28-1) → 1-bromo-2-(2-indanyl)ethane (159011-42-4)

Guidance literature:

With sulfuric acid; hydrogen bromide; In water; for 4h; Heating;

DOI:10.1021/jm00039a019

Reference yield:

inden-1-one (83-33-0) → 1-bromo-2-(2-indanyl)ethane (159011-42-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / H₂SO₄ / dioxane; H₂O / 1 h / Heating

2: 87 percent / H₂, H₂SO₄ / 10percent Pd/C / dioxane; H₂O / 5 h / 40 - 50 °C

3: 83.3 percent / HCl(g) / 0.5 h / Heating

4: 86.4 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

5: 74 percent / 48percent HBr, conc.H₂SO₄ / H₂O / 4 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; water;

DOI:10.1021/jm00039a019

Reference yield:

1-oxoindan-Δ2,α-acetic acid (114915-75-2) → 1-bromo-2-(2-indanyl)ethane (159011-42-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / H₂, H₂SO₄ / 10percent Pd/C / dioxane; H₂O / 5 h / 40 - 50 °C

2: 83.3 percent / HCl(g) / 0.5 h / Heating

3: 86.4 percent / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

4: 74 percent / 48percent HBr, conc.H₂SO₄ / H₂O / 4 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; water;

DOI:10.1021/jm00039a019

upstream raw materials:

2-(indan-2-yl)ethanol

2-(indan-2-yl)acetic acid

inden-1-one

1-oxoindan-Δ^2,α-acetic acid

Refernces

• 1、 Tanaka,Niwa,Nishioka,Yamanaka,Torizuka,Yoshinaga,Kobayashi,Ikeda,Arai. "New potent prolyl endopeptidase inhibitors: Synthesis and structure- activity relationships of indan and tetralin derivatives and their analogues". . p. 2071 - 2078. Retrieved 2007/10/02.