3-(1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID

Base Information

• Chemical Name: 3-(1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID
• CAS No.: 130373-81-8
• Molecular Formula: C15H13NO2
• Molecular Weight: 239.274
• Hs Code.: 2933990090
• Mol file: 130373-81-8.mol

Synonyms:CHEMBRDG-BB 5604831;3-(1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID;TIMTEC-BB SBB007375;3-(1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC ACID;3-(1,3-dihydro-2H-isoindol-2-yl)benzoic acid(SALTDATA: FREE)

Chemical Property of 3-(1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 1.58E-09mmHg at 25°C
• Boiling Point: 467.2°C at 760 mmHg
• Flash Point: 236.3°C
• PSA: 40.54000
• Density: 1.284g/cm³
• LogP: 2.97000

Purity/Quality:

98%min ^*data from raw suppliers

3-(Isoindolin-2-yl)benzoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID

There total 3 articles about 3-(1,3-DIHYDRO-ISOINDOL-2-YL)-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(3-methoxycarbonylphenyl)isoindoline → 2-(3-carboxyphenyl)isoindoline (130373-81-8)

Guidance literature:

2-(3-methoxycarbonylphenyl)isoindoline; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 50 ℃; for 1h;

With hydrogenchloride; In water;

DOI:10.1016/j.jphotochem.2021.113185

Reference yield:

Methyl 3-aminobenzoate (4518-10-9) + α,α'-dibromo-o-xylene (91-13-4) → 2-(3-carboxyphenyl)isoindoline (130373-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 3 h / 50 °C

2: lithium hydroxide / methanol; tetrahydrofuran; water / 1 h / 50 °C

With potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;

DOI:10.1016/j.jphotochem.2021.113185

Reference yield:

meta-aminobenzoic acid (99-05-8,159139-79-4) → 2-(3-carboxyphenyl)isoindoline (130373-81-8)

Guidance literature:

With ethanol;

upstream raw materials:

meta-aminobenzoic acid

Methyl 3-aminobenzoate

α,α'-dibromo-o-xylene