3,5-Difluoro-4-carboxyphenylboronic acid

Base Information

• Chemical Name: 3,5-Difluoro-4-carboxyphenylboronic acid
• CAS No.: 1029716-94-6
• Molecular Formula: C7H5BF2O4
• Molecular Weight: 201.922
• Hs Code.: 2931900090
• Mol file: 1029716-94-6.mol

Synonyms:3,5-Difluoro-4-carboxyphenylboronic acid;4-Borono-2,6-difluorobenzoic acid

Chemical Property of 3,5-Difluoro-4-carboxyphenylboronic acid

Chemical Property:

• Boiling Point: 383.8±52.0 °C(Predicted)
• PKA: 2.22±0.10(Predicted)
• PSA: 77.76000
• Density: 1.58±0.1 g/cm3(Predicted)
• LogP: -0.65720
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3,5-Difluoro-4-carboxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Difluoro-4-carboxyphenylboronic acid

There total 1 articles about 3,5-Difluoro-4-carboxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,5-difluoro-4-formylphenyl)boronic acid (870718-11-9) → 3,5-difluoro-4-carboxyphenylboronic acid (1029716-94-6)

Guidance literature:

With potassium permanganate;

DOI:10.1016/j.tet.2010.11.062

Reference yield:

D-fructose (470-23-5) + 3,5-difluoro-4-carboxyphenylboronic acid (1029716-94-6) → C13H14BF2O9(1-)*H(1+)

Guidance literature:

3,5-difluoro-4-carboxyphenylboronic acid; With alizarin red S; In water; at 40 - 50 ℃; for 5h; Saline buffer;

D-fructose; With sodium hydroxide; In water; pH=7.4; Saline buffer;

DOI:10.1016/j.tet.2010.11.062

Reference yield:

3,5-difluoro-4-carboxyphenylboronic acid (1029716-94-6) + N-(5-bromo-4-fluoro-2-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)phenyl)-4-(trifluoromethyl)-6-(2-(trimethylsilyl)ethoxy)nicotinamide → 2’,3,5-trifluoro-5’-(6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamido)-4‘-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)-[1,1‘-biphenyl]-4-carboxylic acid

Guidance literature:

3,5-difluoro-4-carboxyphenylboronic acid; N-(5-bromo-4-fluoro-2-((3S,5R)-3,4,5-trimethylpiperazin-1-yl)phenyl)-4-(trifluoromethyl)-6-(2-(trimethylsilyl)ethoxy)nicotinamide; With potassium phosphate; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

(3,5-difluoro-4-formylphenyl)boronic acid