D-erythro-Pentaric acid, 3,4-dideoxy-4-methyl-, 5,2-lactone, 1-methyl ester

Base Information

Chemical Name:D-erythro-Pentaric acid, 3,4-dideoxy-4-methyl-, 5,2-lactone, 1-methyl ester
CAS No.:284494-70-8
Molecular Formula:C7H10O4
Molecular Weight:158.1519
Hs Code.:
Mol file:284494-70-8.mol

Synonyms:D-erythro-Pentaric acid, 3,4-dideoxy-4-methyl-, 5,2-lactone, 1-methyl ester

Suppliers and Price of D-erythro-Pentaric acid, 3,4-dideoxy-4-methyl-, 5,2-lactone, 1-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of D-erythro-Pentaric acid, 3,4-dideoxy-4-methyl-, 5,2-lactone, 1-methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of D-erythro-Pentaric acid, 3,4-dideoxy-4-methyl-, 5,2-lactone, 1-methyl ester

There total 5 articles about D-erythro-Pentaric acid, 3,4-dideoxy-4-methyl-, 5,2-lactone, 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129104-44-5,129104-45-6
diethyl 2-hydroxy-4-methylpentanedioate

: 284494-70-8
methyl (2R,4S)-(-)-trans-4-methyl-tetrahydro-5-oxo-2-furancarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: PTSA / benzene / 2 h / 80 °C

1.2: phosphate buffer; porcine pancreatic lipase type II; 1N aq. NaOH / pH 7.4

2.1: phosphate buffer; α-chymotrypsin; 1N NaOH / pH 7.4

With sodium hydroxide; phosphate buffer; toluene-4-sulfonic acid; α-chymotrypsin; In benzene; 1.1: Cyclization / 1.2: Hydrolysis / 2.1: Hydrolysis / 3.1: Methylation;
DOI:10.1016/S0957-4166(00)00057-4

Reference yield:

: 53558-93-3
(R)-tetrahydro-5-oxo-2-furancarboxylic acid

: 284494-70-8
methyl (2R,4S)-(-)-trans-4-methyl-tetrahydro-5-oxo-2-furancarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: LDA; HMPA / tetrahydrofuran / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; 1: Methylation / 2: Methylation;
DOI:10.1016/S0957-4166(00)00057-4

Reference yield:

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: destruxin D₁ Me ester

: 284494-70-8
methyl (2R,4S)-(-)-trans-4-methyl-tetrahydro-5-oxo-2-furancarboxylate

: (2R,4R)-4-Methyl-5-oxo-tetrahydro-furan-2-carboxylic acid methyl ester

Guidance literature:: With hydrogenchloride; acetic acid; Yield given. Multistep reaction. Yields of byproduct given; 1.) H₂O, reflux;
DOI:10.1016/0031-9422(81)85160-6