N-DesMethyl Noscapine-d3

Base Information

• Chemical Name: N-DesMethyl Noscapine-d3
• CAS No.: 92621-03-9
• Molecular Formula: C21H21NO7
• Molecular Weight: 399.39
• Mol file: 92621-03-9.mol

Synonyms:N-DesMethyl Noscapine-d3;Nor-Noscapine

Chemical Property of N-DesMethyl Noscapine-d3

Chemical Property:

• Boiling Point: 583.8±50.0 °C(Predicted)
• PKA: 7.08±0.40(Predicted)
• PSA: 84.48000
• Density: 1.352±0.06 g/cm3(Predicted)
• LogP: 2.86840

Purity/Quality:

>95% ^*data from raw suppliers

Norgnoscopine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-DesMethyl Noscapine-d3

There total 5 articles about N-DesMethyl Noscapine-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

α-narcotine N-oxide (54383-36-7,1850-90-4) → (3S)-6,7-dimethoxy-3-((R)-4-methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo [4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one (92621-03-9,36017-64-8)

Guidance literature:

With ferrous(II) sulfate heptahydrate; In methanol; at -5 ℃; for 8h;

DOI:10.1002/cmdc.201300395

Reference yield: 48.0%

narcotine N-oxide hydrochloride (123618-25-7) → (3S)-6,7-dimethoxy-3-((R)-4-methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo [4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one (92621-03-9,36017-64-8)

Guidance literature:

With ferrous(II) sulfate heptahydrate; In methanol; at 25 ℃; for 12h;

DOI:10.1016/j.lfs.2020.118238

Reference yield:

noscapine-N-oxide hydrochloride → (3S)-6,7-dimethoxy-3-((R)-4-methoxy-5,6,7,8-tetrahydro-[1,3]dioxolo [4,5-g]isoquinolin-5-yl)isobenzofuran-1(3H)-one (92621-03-9,36017-64-8)

Guidance literature:

With ferrous(II) sulfate heptahydrate; In methanol; at -8 ℃; for 8h;

DOI:10.1016/j.bmcl.2020.127489

upstream raw materials:

noscapine

α-narcotine N-oxide

narcotine N-oxide hydrochloride

Downstream raw materials:

(R)-5-((S)-4,5-dimethoxy-1,3-dihydroisobenzofuran-1-yl)-N-ethyl-4-methoxy-9-phenyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-6(5H)-carboxamide

(5R)-5-((S)-4,5-dimethoxy-1,3-dihydroisobenzofuran-1-yl)-Nethyl-4-methoxy-9-(2-methoxyphenyl)-7,8-dihydro-[1,3]dioxolo-[4,5-g]isoquinoline-6(5H)-carboxamide

(R)-5-((S)-4,5-dimethoxy-1,3-dihydroisobenzofuran-1-yl)-N-ethyl-4-methoxy-9-(3-methoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-6(5H)-carboxamide

(R)-5-((S)-4,5-dimethoxy-1,3-dihydroisobenzofuran-1-yl)-N-ethyl-4-methoxy-9-(4-methoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline-6(5H)-carboxamide