(R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran

Base Information

• Chemical Name: (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran
• CAS No.: 915095-90-8
• Molecular Formula: C17H16BrClO2
• Molecular Weight: 367.66474
• Mol file: 915095-90-8.mol

Synonyms:(R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran;(3R)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran;EPG-13A enantiomer;R-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan

Chemical Property of (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran

Chemical Property:

• PSA: 18.46000
• LogP: 4.86100

Purity/Quality:

99%, ^*data from raw suppliers

(R)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran

There total 1 articles about (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (R)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene (915095-90-8)

Guidance literature:

Reference yield: 80.0%

(R)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene (915095-90-8) → C17H11(2)H5BrClO2

Guidance literature:

With water-d2; potassium carbonate; silver carbonate; cyclohexyldiphenylphosphine; In toluene; at 120 ℃; for 12h;

DOI:10.1021/acs.orglett.0c04139

Reference yield:

(R)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene (915095-90-8) + (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one (32469-28-6,55515-28-1,55515-29-2,32384-65-9) → 1-chloro-4-(1-methoxy-D-glucopyranos-1-yl)-2-(4-(R)-tetrahydrofuran-3-yloxy-benzyl)-benzene (915095-95-3)

Guidance literature:

(R)-4-bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.75h;

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; In diethyl ether; pentane; at -78 ℃; for 2h;

With methanesulfonic acid; In methanol; diethyl ether; pentane; at -78 - 20 ℃; for 16h;

Downstream raw materials:

1-chloro-4-(1-methoxy-D-glucopyranos-1-yl)-2-(4-(R)-tetrahydrofuran-3-yloxy-benzyl)-benzene