DARIFENACIN

Base Information

• Chemical Name: DARIFENACIN
• CAS No.: 133099-05-5
• Molecular Formula: C28H30N2O2
• Molecular Weight: 426.55
• Mol file: 133099-05-5.mol

Synonyms:(R)-Darifenacin

Chemical Property of DARIFENACIN

Chemical Property:

• PSA: 55.56000
• LogP: 4.59570

Purity/Quality:

(R)?-?Darifenacin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)?-?Darifenacin is the enantiomeric impurity of Darifenacin (D193400), a medication used to treat urinary incontinence.

Technology Process of DARIFENACIN

There total 1 articles about DARIFENACIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydro-5-(2-bromoethyl)benzofuran (127264-14-6) + 3-(R)-(1-carbamoyl-1,1-diphenylmethyl)pyrrolidine (134002-27-0,103887-32-7) → 2-{(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide (133099-05-5,133033-93-9)

Guidance literature:

With potassium hydroxide; In acetonitrile; Reflux;

Reference yield:

2-{(3R)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide (133099-05-5,133033-93-9) → (3R)-2-{1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide hydrobromide (1092800-15-1)

Guidance literature:

With hydrogen bromide; In butanone;

upstream raw materials:

2,3-dihydro-5-(2-bromoethyl)benzofuran

3-(R)-(1-carbamoyl-1,1-diphenylmethyl)pyrrolidine

Downstream raw materials:

(3R)-2-{1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl}-2,2-diphenylacetamide hydrobromide

Refernces