5alpha-Pregnan-20-one, 3alpha,11beta-dihydroxy-

Base Information

Chemical Name:5alpha-Pregnan-20-one, 3alpha,11beta-dihydroxy-
CAS No.:23930-29-2
Molecular Formula:
Molecular Weight:334.49
Hs Code.:
DSSTox Substance ID:DTXSID301275594
Nikkaji Number:J121.984G
ChEMBL ID:CHEMBL2322582
Mol file:23930-29-2.mol

Synonyms:23930-29-2;3alpha,11beta-Dihydroxy-5alpha-pregnan-20-one;5.alpha.-Pregnan-20-one, 3.alpha.,11.beta.-dihydroxy-;Pregnan-20-one, 3,11-dihydroxy-, (3.alpha.,5.alpha.,11.beta.)-;1-[(3R,5S,8S,9S,10S,11S,13S,14S,17S)-3,11-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone;3,11-Dihydroxypregnan-20-one;3,11-Dihydroxypregnan-20-one #;CHEMBL2322582;SCHEMBL11440482;NFVCQZNBRFPYOP-DAVHWALQSA-N;DTXSID301275594;3a,11b-di-hydroxy-5a-pregnan-20-one;(3alpha,5alpha,11beta)-3,11-Dihydroxypregnan-20-one

Suppliers and Price of 5alpha-Pregnan-20-one, 3alpha,11beta-dihydroxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3α,11β-Dihydroxy-5α-pregnan-20-one
2.5mg
$ 325.00

Total 3 raw suppliers

Chemical Property of 5alpha-Pregnan-20-one, 3alpha,11beta-dihydroxy-

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:334.25079494
Heavy Atom Count:24
Complexity:531

Purity/Quality:

99% ^*data from raw suppliers

3α,11β-Dihydroxy-5α-pregnan-20-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1CCC2C1(CC(C3C2CCC4C3(CCC(C4)O)C)O)C
Isomeric SMILES:CC(=O)[C@H]1CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)O)C
Uses 3α,11β-Dihydroxy-5α-pregnan-20-one is a metabolite of progesterone (P755900). Progesterone is a cholesterol derived hormone which is critical for pregnancy. Progesterone is an immunomodulatory female sex steroid.

Technology Process of 5alpha-Pregnan-20-one, 3alpha,11beta-dihydroxy-

There total 18 articles about 5alpha-Pregnan-20-one, 3alpha,11beta-dihydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23930-32-7
20,20-ethylenedioxy-5α-pregnane-3α,11β-diol

: 23930-29-2
5α-pregnan-3α,11β-diol-20-one

Guidance literature:: With toluene-4-sulfonic acid; In acetone; at 55 ℃; for 0.25h;
DOI:10.1021/jm3016365

Reference yield:

: 3684-81-9
3β-acetoxy-5α-pregnane-11,20-dione

: 23930-29-2
5α-pregnan-3α,11β-diol-20-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / methanol; water / 1 h / Reflux

2: pyridine / 2 h / 0 °C

3: potassium nitrite / N,N-dimethyl-formamide / 130 °C

4: toluene-4-sulfonic acid

5: lithium aluminium tetrahydride / tetrahydrofuran

6: toluene-4-sulfonic acid / acetone / 0.25 h / 55 °C

With pyridine; lithium aluminium tetrahydride; potassium nitrite; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm3016365

Reference yield:

: 23930-19-0
Alphaxalone

: 23930-29-2
5α-pregnan-3α,11β-diol-20-one

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid

2: lithium aluminium tetrahydride / tetrahydrofuran

3: toluene-4-sulfonic acid / acetone / 0.25 h / 55 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; acetone;
DOI:10.1021/jm3016365