(S)-2-Amino-3,3-dimethyl-N-pyridin-2-ylbutyramide

Base Information Edit

Chemical Name:(S)-2-Amino-3,3-dimethyl-N-pyridin-2-ylbutyramide
CAS No.:171764-07-1
Molecular Formula:C₁₁H₁₇N₃O
Molecular Weight:207.275
Hs Code.:
DSSTox Substance ID:DTXSID80938039
Nikkaji Number:J2.924.730G
Wikidata:Q82914284
Mol file:171764-07-1.mol

Synonyms:171764-07-1;(S)-2-AMINO-3,3-DIMETHYL-N-PYRIDIN-2-YLBUTYRAMIDE;(S)-2-Amino-3,3-dimethyl-N-(pyridin-2-yl)butanamide;(S)-2-Amino-3,3-dimethyl-N-2-pyridinylbutanamide;(2S)-2-Amino-3,3-dimethyl-N-2-pyridinylbutanamide;(2S)-2-amino-3,3-dimethyl-N-pyridin-2-ylbutanamide;97% pound not 99%ee;SCHEMBL1254966;DTXSID80938039;ACNZLRUIGXMARU-SECBINFHSA-N;WGA76407;MFCD14590239;AS-75931;CS-0093600;D75412;2-Amino-3,3-dimethyl-N-(pyridin-2-yl)butanimidic acid;(2S)-2-Amino-3,3-dimethyl-N-2-pyridinylbutanamide, 98%, (99% ee)

Suppliers and Price of (S)-2-Amino-3,3-dimethyl-N-pyridin-2-ylbutyramide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
(2S)-2-Amino-3,3-dimethyl-N-2-pyridinylbutanamide, 98%, (99% ee)
100mg
$ 89.00

JR MediChem
Butanamide,2-amino-3,3-dimethyl-N-2-pyridinyl-,(2S)- 96%
1g
$ 980.00

Total 4 raw suppliers

Chemical Property of (S)-2-Amino-3,3-dimethyl-N-pyridin-2-ylbutyramide Edit

Chemical Property:

Boiling Point:391.7±22.0 °C(Predicted)
PKA:12.82±0.70(Predicted)
PSA：68.01000
Density:1.115±0.06 g/cm3(Predicted)
LogP:2.16680
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:207.137162174
Heavy Atom Count:15
Complexity:222

Purity/Quality:

98.5% ^*data from raw suppliers

(2S)-2-Amino-3,3-dimethyl-N-2-pyridinylbutanamide, 98%, (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C(C(=O)NC1=CC=CC=N1)N
Isomeric SMILES:CC(C)(C)[C@@H](C(=O)NC1=CC=CC=N1)N

Technology Process of (S)-2-Amino-3,3-dimethyl-N-pyridin-2-ylbutyramide

There total 3 articles about (S)-2-Amino-3,3-dimethyl-N-pyridin-2-ylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 372199-77-4
C₁₆H₂₅N₃O₃

: 171764-07-1
(2S)-2-amino-3,3-dimethyl-N-(pyridin-2-yl)butanamide

Guidance literature:: C₁₆H₂₅N₃O₃; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In water; ethyl acetate; pH=8;
DOI:10.1039/c0cc00917b

Reference yield:

: 504-29-0
2-aminopyridine

: 62965-35-9
N-tert-butyloxycarbonyl-L-tert-leucine

: 171764-07-1
(2S)-2-amino-3,3-dimethyl-N-(pyridin-2-yl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/anie.201100160