2-(3-(AMinoMethyl)phenyl)ethanol

Base Information

• Chemical Name: 2-(3-(AMinoMethyl)phenyl)ethanol
• CAS No.: 1379356-00-9
• Molecular Formula: C9H13NO
• Molecular Weight: 151.20562
• Hs Code.: 2922199090
• Mol file: 1379356-00-9.mol

Synonyms:2-(3-(AMinoMethyl)phenyl)ethanol

Chemical Property of 2-(3-(AMinoMethyl)phenyl)ethanol

Chemical Property:

• PSA: 46.25000
• LogP: 1.38040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

≥95% ^*data from raw suppliers

2-(3-(Aminomethyl)phenyl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-(AMinoMethyl)phenyl)ethanol

There total 4 articles about 2-(3-(AMinoMethyl)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(3-(aminomethyl)phenyl)acetate (259818-63-8) → 2-(3-(aminomethyl)phenyl)ethan-1-ol (1379356-00-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

Reference yield:

3-(2-hydroxyethyl)benzonitrile (193290-27-6) → 2-(3-(aminomethyl)phenyl)ethan-1-ol (1379356-00-9)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 80 ℃; for 12h;

Reference yield:

3-cyanobromobenzene (6952-59-6) → 2-(3-(aminomethyl)phenyl)ethan-1-ol (1379356-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 89 percent / Pd(PPh₃)4; LiCl / tetrahydrofuran / 12 h / 80 °C

2.1: BH₃ / tetrahydrofuran / 1 h / 0 °C

2.2: 69 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 0.67 h / 0 °C

3.1: LiBH₄ / tetrahydrofuran / 12 h / 80 °C

With lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane; lithium chloride; In tetrahydrofuran;

upstream raw materials:

3-(2-hydroxyethyl)benzonitrile

3-cyanobromobenzene

3-cyanostyrene

ethyl 2-(3-(aminomethyl)phenyl)acetate

Refernces

• 1、 Lee, B. C.,Choe, Y. S.,Lee, K. H.,Kim, B.-T.,Chi, D. Y.. "New Potential and Practical MIBG Analogs for PET: meta-(3-[18F]Fluoroalkyl)benzylguanidines". . p. S404 - S406. Retrieved 2007/10/03.