Multi-step reaction with 10 steps
1: sulfuric acid; sodium nitrite; hydrogenchloride / water / 0 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
3: dicyclohexyl-carbodiimide; dmap; benzotriazol-1-ol / dichloromethane / 0 - 20 °C
4: palladium on activated charcoal; hydrogen / methanol / 1.5 h / 20 °C
5: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
6: palladium on activated charcoal; hydrogen / methanol / 1.5 h / 20 °C
7: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
8: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C
9: palladium on activated charcoal; hydrogen / methanol / 1.5 h / 20 °C
10: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
With
hydrogenchloride; dmap; sulfuric acid; palladium on activated charcoal; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium nitrite;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;