2,2,2-Trifluoro-1-[2-(4-methylphenyl)-5-morpholinooxazol-4-yl]ethanone

Base Information

• Chemical Name: 2,2,2-Trifluoro-1-[2-(4-methylphenyl)-5-morpholinooxazol-4-yl]ethanone
• CAS No.: 51770-11-7
• Molecular Formula: C₁₆H₁₅F₃N₂O₃
• Molecular Weight: 340.302
• Mol file: 51770-11-7.mol

Synonyms:2,2,2-Trifluoro-1-[2-(4-methylphenyl)-5-morpholinooxazol-4-yl]ethanone

Chemical Property of 2,2,2-Trifluoro-1-[2-(4-methylphenyl)-5-morpholinooxazol-4-yl]ethanone

Chemical Property:

• PSA: 55.57000
• LogP: 3.29660

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-Trifluoro-1-[2-(4-methylphenyl)-5-morpholinooxazol-4-yl]ethanone

There total 1 articles about 2,2,2-Trifluoro-1-[2-(4-methylphenyl)-5-morpholinooxazol-4-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,2,2-trifluoro-1-(5-morpholin-4-yl-2-p-tolyl-oxazol-4-yl)-ethanone (51770-11-7)

Guidance literature:

Amid 8c, TFA-Anhydrid.;

DOI:10.1016/S0040-4020(01)97026-7

Reference yield:

2,2,2-trifluoro-1-(5-morpholin-4-yl-2-p-tolyl-oxazol-4-yl)-ethanone (51770-11-7) → 4-(2-p-tolyl-oxazol-5-yl)-morpholine (51770-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. NaOH, (ii) aq. HCl

2: toluene / Heating

In toluene;

Reference yield:

2,2,2-trifluoro-1-(5-morpholin-4-yl-2-p-tolyl-oxazol-4-yl)-ethanone (51770-11-7) → 5-morpholin-4-yl-2-p-tolyl-oxazole-4-carboxylic acid (51770-16-2)

Guidance literature:

Multistep reaction; (i) aq. NaOH, (ii) aq. HCl;

Downstream raw materials:

5-morpholin-4-yl-2-p-tolyl-oxazole-4-carboxylic acid

4-(2-p-tolyl-oxazol-5-yl)-morpholine

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