4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER

Base Information

• Chemical Name: 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER
• CAS No.: 917255-45-9
• Molecular Formula: C₁₅H₂₀N₂O₄
• Molecular Weight: 292.335
• Mol file: 917255-45-9.mol

Synonyms:4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER

Chemical Property of 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER

Chemical Property:

• PSA: 81.86000
• LogP: 1.92610

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER

There total 11 articles about 4-AMINO-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methyl trans-1-benzyloxycarbonyl-4-azidopiperidine-2-carboxylate → 2-methyl trans-1-benzyloxycarbonyl-4-aminopiperidine-2-carboxylate (917255-45-9)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 48h;

DOI:10.1002/jhet.5570430539

Reference yield: 65.0%

2-methyl cis-1-benzyloxycarbonyl-4-azidopiperidine-2-carboxylate → 2-methyl cis-1-benzyloxycarbonyl-4-aminopiperidine-2-carboxylate (917255-45-9)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; for 48h;

DOI:10.1002/jhet.5570430539

Reference yield:

2-methyl trans-1-benzyloxycarbonyl-4-bromopiperidine-2-carboxylate → 2-methyl cis-1-benzyloxycarbonyl-4-aminopiperidine-2-carboxylate (917255-45-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaN₃ / dimethylformamide / 72 h / 70 °C

2: 65 percent / PPh₃ / tetrahydrofuran; H₂O / 48 h / 60 °C

With sodium azide; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570430539

upstream raw materials:

methyl cis-4-hydroxy-2-piperidinecarboxylate

2-methyl 1-(phenylmethyl) cis-4-hydroxy-1,2-piperidinedicarboxylate

benzyl chloroformate