tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

Base Information

Chemical Name:tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide
CAS No.:1340481-91-5
Molecular Formula:C₁₁H₁₇NO₅S
Molecular Weight:275.326
Hs Code.:2934999090
Mol file:1340481-91-5.mol

Synonyms:tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

Suppliers and Price of tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide
100mg
$ 456.00

Arctom
tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide 98%
250mg
$ 1548.00

American Custom Chemicals Corporation
tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide 95.00%
5MG
$ 501.85

Total 8 raw suppliers

Chemical Property of tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

Chemical Property:

PSA：89.13000
LogP:1.38220
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses This spirocyclic building block was first synthesized by Carreira and coworkers. It provides a new area of chemical space with straightforward functional handles for further diversification.Synthesis of Novel Azaspiro[3.4]octanes as Multifunctional Modules in Drug Discovery

Technology Process of tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide

There total 6 articles about tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1340481-90-4
C₁₁H₁₉NO₅S

: 1340481-91-5
C₁₁H₁₇NO₅S

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol2025313

Reference yield:

: 1340481-89-1
C₁₁H₁₉NO₃S

: 1340481-91-5
C₁₁H₁₇NO₅S

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

With sodium hydrogencarbonate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/ol2025313

Reference yield:

: 1340481-85-7
C₁₇H₂₃NO₄S

: 1340481-91-5
C₁₁H₁₇NO₅S

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1.75 h / -78 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / toluene / -78 °C / Inert atmosphere

3.1: pyridine; p-toluenesulfonyl chloride / 0 - 20 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene; 1.2: Claisen condensation;
DOI:10.1021/ol2025313