3-AMINO-3-BENZO[1,3]DIOXOL-5-YL-PROPIONIC ACID

Base Information

• Chemical Name: 3-AMINO-3-BENZO[1,3]DIOXOL-5-YL-PROPIONIC ACID
• CAS No.: 72071-75-1
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.202
• Hs Code.: 2932999099
• Mol file: 72071-75-1.mol

Synonyms:3-AMINO-3-(BENZO[D][1,3]DIOXOL-5-YL)PROPANOIC ACID;3-AMINO-3-(1,3-BENZODIOXOL-5-YL)PROPANOIC ACID;AKOS BBS-00004676;3-(1,3-BENZODIOXOL-5-YL)-BETA-ALANINE;RARECHEM AK HC S236

Chemical Property of 3-AMINO-3-BENZO[1,3]DIOXOL-5-YL-PROPIONIC ACID

Chemical Property:

• Melting Point: 213-214°C
• PSA: 81.78000
• LogP: 1.59010

Purity/Quality:

99%+, ^*data from raw suppliers

3-AMINO-3-BENZO[1,3]DIOXOL-5-YL-PROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-3-BENZO[1,3]DIOXOL-5-YL-PROPIONIC ACID

There total 18 articles about 3-AMINO-3-BENZO[1,3]DIOXOL-5-YL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl (R)-3-amino-3-(piperon-3-yl)propanoate (250374-94-8) → (R)-3-amino-3-(piperon-3-yl)propanoic acid (72071-75-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/j.tetasy.2007.06.008

Reference yield: 96.0%

tert-butyl (S)-3-amino-3-(piperon-3-yl)propanoate (181517-85-1) → (S)-3-amino-3-(piperon-3-yl)propanoic acid (72071-75-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/j.tetasy.2007.06.008

Reference yield: 76.0%

piperonal (120-57-0,30024-74-9) + ammonium acetate (631-61-8,92206-38-7) → (S)-3-amino-3-(3,4-methylenedioxyphenyl)propionic acid (129042-60-0,72071-75-1)

Guidance literature:

piperonal; ammonium acetate; With malonic acid; In ethanol; Reflux;

With ammonium hydroxide; In methanol; at 20 ℃;

upstream raw materials:

piperonal

malonic acid

hydroxylamine

3,4-methylenedioxy-trans-cinnamic acid

Downstream raw materials:

m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoyl-β-(3,4-methylenedioxyphenyl)-β-alanine

Refernces

• 1、 Bea, Han-Seop,Park, Hye-Jeong,Lee, Sang-Hyeup,Yun, Hyungdon. "Kinetic resolution of aromatic β-amino acids by ω-transaminase". supporting information; experimental part. p. 5894 - 5896. Retrieved 2011/06/23.
• 2、 Davies, Stephen G.,Mulvaney, Andrew W.,Russell, Angela J.,Smith, Andrew D.. "Parallel synthesis of homochiral β-amino acids". . p. 1554 - 1566. Retrieved 2008/02/09.