1-(TETRAHYDRO-PYRAN-4-YL)-PIPERAZINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 1-(TETRAHYDRO-PYRAN-4-YL)-PIPERAZINE DIHYDROCHLORIDE
• CAS No.: 790223-65-3
• Molecular Formula: C₉H₁₈N₂O*2ClH
• Molecular Weight: 243.177
• Hs Code.: 2933599590
• Mol file: 790223-65-3.mol

Synonyms:1-(TETRAHYDRO-PYRAN-4-YL)-PIPERAZINE DIHYDROCHLORIDE;1-(Tetrahydro-2H-pyran-4-yl)-piperazine 2HCl

Chemical Property of 1-(TETRAHYDRO-PYRAN-4-YL)-PIPERAZINE DIHYDROCHLORIDE

Chemical Property:

• PSA: 24.50000
• LogP: 1.94130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-(Tetrahydro-2H-pyran-4-yl)piperazine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(TETRAHYDRO-PYRAN-4-YL)-PIPERAZINE DIHYDROCHLORIDE

There total 2 articles about 1-(TETRAHYDRO-PYRAN-4-YL)-PIPERAZINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 1-(tetrahydro-2H-pyran-4-yl)piperazine dihydrochloride (790223-65-3)

Guidance literature:

Reference yield:

4-(tetrahydro-2H-pyran-4-yl)piperazine-1-carboxylic acid tert-butyl ester (706759-32-2) → 1-(tetrahydro-2H-pyran-4-yl)piperazine dihydrochloride (790223-65-3)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 16h;

Reference yield:

1-(tetrahydro-2H-pyran-4-yl)piperazine dihydrochloride (790223-65-3) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-(4-nitrophenyl)-4-(tetrahydro-2H-pyran-4-yl)piperazine

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

upstream raw materials:

4-(tetrahydro-2H-pyran-4-yl)piperazine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

4-[4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl]aniline

Refernces

• 1、 -. "NK-2 ANTAGONIST BASIC LINEAR COMPOUNDS AND FORMULATIONS CONTAINING THEM". Page 18. . Retrieved 2010/02/09.