Technology Process of (S)-1-(1-benzyl-1H-indazol-6-yl)ethane-1,2-diol
There total 4 articles about (S)-1-(1-benzyl-1H-indazol-6-yl)ethane-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium osmate(VI) dihydrate; potassium hexacyanoferrate (III); potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether;
In
water; tert-butyl alcohol;
for 5h;
Product distribution / selectivity;
Inert atmosphere;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h
1.2: 12 h / 20 - 150 °C
2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere
3.1: potassium carbonate; potassium osmate(VI) dihydrate; potassium hexacyanoferrate(III); 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine / water; tert-butyl alcohol / 6 h / 0 - 10 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium osmate(VI) dihydrate; potassium tert-butylate; potassium carbonate; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; potassium hexacyanoferrate(III);
In
1,2-dimethoxyethane; water; dimethyl sulfoxide; tert-butyl alcohol;
2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm5005336
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere
2: potassium carbonate; potassium osmate(VI) dihydrate; potassium hexacyanoferrate(III); 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine / water; tert-butyl alcohol / 6 h / 0 - 10 °C
With
bis-triphenylphosphine-palladium(II) chloride; potassium osmate(VI) dihydrate; potassium carbonate; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; potassium hexacyanoferrate(III);
In
1,2-dimethoxyethane; water; tert-butyl alcohol;
1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm5005336
