PU-WS13

Base Information

Chemical Name:PU-WS13
CAS No.:1454619-14-7
Molecular Formula:C₁₇H₂₀Cl₂N₆S
Molecular Weight:411.358
Hs Code.:
Mol file:1454619-14-7.mol

Synonyms:PU-WS13;8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine;6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine

Suppliers and Price of PU-WS13

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
PU-WS13
100mg
$ 790.00

DC Chemicals
PU-WS13 >98%
1 g
$ 2500.00

DC Chemicals
PU-WS13 >98%
250 mg
$ 1300.00

DC Chemicals
PU-WS13 >98%
100 mg
$ 700.00

Crysdot
PU-WS13 98+%
50mg
$ 431.00

Crysdot
PU-WS13 98+%
5mg
$ 63.00

Crysdot
PU-WS13 98+%
10mg
$ 100.00

ChemScene
PU-WS13 99.34%
5mg
$ 108.00

ChemScene
PU-WS13 99.34%
50mg
$ 672.00

ChemScene
PU-WS13 99.34%
10mg
$ 156.00

Total 17 raw suppliers

Chemical Property of PU-WS13

Chemical Property:

Appearance/Colour:White solid
Boiling Point:617.4±65.0 °C(Predicted)
PKA:10.15±0.29(Predicted)
PSA：106.95000
Density:1.47±0.1 g/cm3(Predicted)
LogP:5.22670
Storage Temp.:2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

PU-WS13 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.
Uses PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments.

Technology Process of PU-WS13

There total 11 articles about PU-WS13 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.2%

: 17231-94-6
3,5-dichlorothiophenol

: 8-bromo-9-(3-((isopropyl)amino)-n-propyl)adenine

: 1454619-14-7
8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine

Guidance literature:: 3,5-dichlorothiophenol; With sodium hydride; In N,N-dimethyl-d₆-formamide; at 20 ℃; for 1h; Inert atmosphere;

8-bromo-9-(3-((isopropyl)amino)-n-propyl)adenine; In N,N-dimethyl-formamide; at 120 ℃; for 6h;

Reference yield: 35.0%

: 8-((3,5-dichlorophenyl)thio)-9H-purin-6-amine

: 905449-67-4
3-(tert-butoxycarbonyl-isopropylamino)propyl tosylate

: 1454619-14-7
8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine

: 8-((3,5-dichlorophenyl)thio)-3-(3-(isopropylamino)propyl)-3H-purin-6-amine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00197