N-(4-methoxybenzyl)piperidine-4-carboxamide

Base Information

Chemical Name:N-(4-methoxybenzyl)piperidine-4-carboxamide
CAS No.:380608-75-3
Molecular Formula:C14H20N2O2
Molecular Weight:248.32
Hs Code.:2933399090
DSSTox Substance ID:DTXSID20358272
Wikidata:Q82138732
ChEMBL ID:CHEMBL1532966
Mol file:380608-75-3.mol

Synonyms:N-(4-methoxybenzyl)piperidine-4-carboxamide;380608-75-3;N-[(4-methoxyphenyl)methyl]piperidine-4-carboxamide;N-(4-methoxybenzyl)-4-piperidinecarboxamide;SMR000071066;Cambridge id 6577830;MLS000062257;CHEMBL1532966;SCHEMBL13745650;DTXSID20358272;HMS1588P14;HMS2377B15;MFCD02922410;STK024023;AKOS000166014;BS-36690;EN300-86620;AB00110776-01;SR-01000237613;SR-01000237613-1;Z228586692

Suppliers and Price of N-(4-methoxybenzyl)piperidine-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemBridge Corporation
N-(4-methoxybenzyl)piperidine-4-carboxamide 95%
5 g
$ 133.00

American Custom Chemicals Corporation
N-(4-METHOXYBENZYL)PIPERIDINE-4-CARBOXAMIDE 95.00%
5G
$ 1168.42

American Custom Chemicals Corporation
N-(4-METHOXYBENZYL)PIPERIDINE-4-CARBOXAMIDE 95.00%
2.5G
$ 983.88

American Custom Chemicals Corporation
N-(4-METHOXYBENZYL)PIPERIDINE-4-CARBOXAMIDE 95.00%
1G
$ 721.57

AK Scientific
N-(4-Methoxybenzyl)piperidine-4-carboxamide
5g
$ 279.00

Total 5 raw suppliers

Chemical Property of N-(4-methoxybenzyl)piperidine-4-carboxamide

Chemical Property:

Vapor Pressure:4.34E-09mmHg at 25°C
Boiling Point:472.3°C at 760 mmHg
Flash Point:239.4°C
PSA：50.36000
Density:1.092g/cm³
LogP:2.03070
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:248.152477885
Heavy Atom Count:18
Complexity:257

Purity/Quality:

98% ^*data from raw suppliers

N-(4-methoxybenzyl)piperidine-4-carboxamide 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)CNC(=O)C2CCNCC2

Technology Process of N-(4-methoxybenzyl)piperidine-4-carboxamide

There total 3 articles about N-(4-methoxybenzyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350717-31-6
4-(4-methoxy-benzylcarbamoyl)-piperidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

: 380608-75-3
piperidine-4-carboxylic acid 4-methoxy-benzylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1021/jo010111w

Reference yield:

: 498-94-2
isonipecotic acid

: 380608-75-3
piperidine-4-carboxylic acid 4-methoxy-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / triethylamine / tetrahydrofuran; H₂O / 20 °C

2: 82 percent / EDCI; HOBt; Et₃N / CHCl₃; dimethylformamide / 16 h / 20 °C

3: TFA / CH₂Cl₂ / 2.5 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo010111w

Reference yield:

: 350716-60-8
piperidine-1,4-dicarboxylic acid mono-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethylundecyl) ester

: 380608-75-3
piperidine-4-carboxylic acid 4-methoxy-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / EDCI; HOBt; Et₃N / CHCl₃; dimethylformamide / 16 h / 20 °C

2: TFA / CH₂Cl₂ / 2.5 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo010111w