Proline, 3-hydroxy-3-methyl-, ethyl ester (9CI)

Base Information

Chemical Name:Proline, 3-hydroxy-3-methyl-, ethyl ester (9CI)
CAS No.:263025-37-2
Molecular Formula:C₈H₁₅NO₃
Molecular Weight:173.212
Hs Code.:
Mol file:263025-37-2.mol

Synonyms:Proline, 3-hydroxy-3-methyl-, ethyl ester (9CI)

Suppliers and Price of Proline, 3-hydroxy-3-methyl-, ethyl ester (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Proline, 3-hydroxy-3-methyl-, ethyl ester (9CI)

Chemical Property:

PSA：58.56000
LogP:-0.00880

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of Proline, 3-hydroxy-3-methyl-, ethyl ester (9CI)

There total 3 articles about Proline, 3-hydroxy-3-methyl-, ethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 263025-19-0
3-hydroxy-3-methyl-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-ethyl ester

: 263025-37-2
β-hydroxy-β-methylproline ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ja993791h

Reference yield:

: 129228-72-4
(3-oxo-butylamino)-acetic acid ethyl ester

: 263025-37-2
β-hydroxy-β-methylproline ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1M aq. NaOH / dioxane / 20 °C

2: 38 percent / tBuOK / toluene / 0 °C

3: TFA / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; potassium tert-butylate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; toluene; 1: Acylation / 2: Cyclization / 3: deprotection;
DOI:10.1021/ja993791h

Reference yield:

: 179686-58-9
N-[(1,1-dimethylethoxy)carbonyl]-N-(3-oxobutyl)glycine ethyl ester

: 263025-37-2
β-hydroxy-β-methylproline ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / tBuOK / toluene / 0 °C

2: TFA / CH₂Cl₂ / 3 h / 20 °C

With potassium tert-butylate; trifluoroacetic acid; In dichloromethane; toluene; 1: Cyclization / 2: deprotection;
DOI:10.1021/ja993791h