Cerdulatinib

Base Information

Chemical Name:Cerdulatinib
CAS No.:1198300-79-6
Molecular Formula:C20H27N7O3S
Molecular Weight:445.545
Hs Code.:
Mol file:1198300-79-6.mol

Synonyms:Cerdulatinib;PRT-062070;4-(cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide PRT062070;Cerdulatinib(PRT-062070;PRT2070);4-(Cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide

Suppliers and Price of Cerdulatinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cerdulatinib(PRT2070)
100mg
$ 590.00

DC Chemicals
Cerdulatinib(PRT-062070;PRT2070) >98%
250 mg
$ 750.00

Crysdot
Cerdulatinib 98+%
100mg
$ 636.00

Crysdot
Cerdulatinib 98+%
250mg
$ 820.00

Crysdot
Cerdulatinib 98+%
50mg
$ 368.00

ChemScene
Cerdulatinib 99.00%
10mg
$ 144.00

ChemScene
Cerdulatinib 99.00%
5mg
$ 108.00

ChemScene
Cerdulatinib 99.00%
200mg
$ 1104.00

ChemScene
Cerdulatinib 99.00%
50mg
$ 480.00

ChemScene
Cerdulatinib 99.00%
100mg
$ 744.00

Total 28 raw suppliers

Chemical Property of Cerdulatinib

Chemical Property:

Boiling Point:741.9±70.0 °C(Predicted)
PKA:14.17±0.50(Predicted)
PSA：141.93000
Density:1.44±0.1 g/cm3(Predicted)
LogP:3.29510
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99%, ^*data from raw suppliers

Cerdulatinib(PRT2070) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Cerdulatinib (PRT2070), acts as a novel oral and dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Preferentially selects for JAK inhibitors (JAK1 and JAK3 primarily), preventing cytokine mediated signaling and functional responses varying cell types. Potential anti-cancer agent.

Technology Process of Cerdulatinib

There total 2 articles about Cerdulatinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 611400-14-7
4-[4-(ethylsulfonyl)-1-piperazin-1-yl]phenylamine

: C₉H₁₂N₄OS

: 1198300-79-6
4-(cyclopropylamino)-2-((4-(4-(ethanesulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

Guidance literature:: C₉H₁₂N₄OS; With 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; at 0 - 25 ℃; for 1h; Large scale;

4-[4-(ethylsulfonyl)-1-piperazin-1-yl]phenylamine; In 1-methyl-pyrrolidin-2-one; at 40 ℃; for 21.2833h; Large scale;

Reference yield:

: 1198300-79-6
4-(cyclopropylamino)-2-((4-(4-(ethanesulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

Guidance literature:

Reference yield:

: 1198300-79-6
4-(cyclopropylamino)-2-((4-(4-(ethanesulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide

: 1369761-01-2
4-(cyclopropylamino)-2-({4-[4-(ethylsulfonyl)piperazin-1-yl]phenyl}amino)pyrimidine-5-carboxamide hydrochloride

Guidance literature:: 4-(cyclopropylamino)-2-((4-(4-(ethanesulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide; With hydrogenchloride; In ethanol; water; dimethyl sulfoxide; at 20 - 80 ℃; for 19.5h; Large scale;

With hydrogenchloride; In water; at 20 - 80 ℃; for 19.5h; Temperature; Large scale;