3β,5-Dihydroxy-5α-androstane-17β-carboxylic acid methyl ester

Base Information

• Chemical Name: 3β,5-Dihydroxy-5α-androstane-17β-carboxylic acid methyl ester
• CAS No.: 55955-57-2
• Molecular Formula: C21H34O4
• Molecular Weight: 350.499
• Mol file: 55955-57-2.mol

Synonyms:3β,5-Dihydroxy-5α-androstane-17β-carboxylic acid methyl ester

Chemical Property of 3β,5-Dihydroxy-5α-androstane-17β-carboxylic acid methyl ester

Chemical Property:

• Boiling Point: 458.8±45.0 °C(Predicted)
• PKA: 14.70±0.70(Predicted)
• PSA: 66.76000
• Density: 1.166±0.06 g/cm3(Predicted)
• LogP: 3.29410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3β,5-Dihydroxy-5α-androstane-17β-carboxylic acid methyl ester

There total 5 articles about 3β,5-Dihydroxy-5α-androstane-17β-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxy-3β-acetoxy-21-nor-5β-pregnanoic acid-(20)-methyl ester (55956-03-1) → 3β,5-dihydroxy-21-nor-5β-pregnanoic acid-(20)-methyl ester (55955-57-2)

Guidance literature:

With potassium hydroxide; Behandeln des Reaktionsprodukts mit Diazomethan in Aether;

DOI:10.1002/hlca.19490320519

Reference yield:

5-hydroxy-3β-acetoxy-21-nor-5β.14β.17βH-pregnanoic acid-(20)-methyl ester (96611-84-6) → 3β,5-dihydroxy-21-nor-5β.14β.17βH-pregnanoic acid-(20)-methyl ester (55955-57-2)

Guidance literature:

With potassium hydroxide; Behandeln des Reaktionsprodukts mit Diazomethan in Aether;

DOI:10.1002/hlca.19470300732

Reference yield:

5.14-dihydroxy-3β-acetoxy-5β,14β-androstane-carboxylic acid-(17α) (96768-32-0) → 3β,5-dihydroxy-21-nor-5β.14β.17βH-pregnanoic acid-(20)-methyl ester (55955-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether; methanol

2: pyridine; phosphorus oxychloride; water / Hydrierung des Reaktionsprodukts an Platin in Essigsaeure

3: methanol. KOH-solution / Behandeln des Reaktionsprodukts mit Diazomethan in Aether

With pyridine; methanol; potassium hydroxide; diethyl ether; water; trichlorophosphate;

DOI:10.1002/hlca.19470300732

upstream raw materials:

5-hydroxy-3β-acetoxy-21-nor-5β-pregnanoic acid-(20)-methyl ester

5-hydroxy-3β-acetoxy-21-nor-5β.14β.17βH-pregnanoic acid-(20)-methyl ester

5.14-dihydroxy-3β-acetoxy-5β,14β-androstane-carboxylic acid-(17α)

5.14-dihydroxy-3β-acetoxy-21-nor-5β.14β.17βH-pregnanoic acid-(20)-methyl ester

Downstream raw materials:

3-oxo-androst-4-ene-17β-carboxylic acid methyl ester