NSC-12

Base Information

Chemical Name:NSC-12
CAS No.:102586-30-1
Molecular Formula:C₂₄H₃₄F₆O₃
Molecular Weight:484.523
Hs Code.:
Mol file:102586-30-1.mol

Synonyms:21-(Hydroxy(bistrifluoromethyl)methyl)pregnane-3,20-diol;Pregn-5-ene-3,20-diol,21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl);

Suppliers and Price of NSC-12

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
NSC-12 >98%
1 g
$ 3500.00

DC Chemicals
NSC-12 >98%
250 mg
$ 1750.00

Cayman Chemical
NSC 12 ≥98%
25mg
$ 406.00

Cayman Chemical
NSC 12 ≥98%
10mg
$ 188.00

Cayman Chemical
NSC 12 ≥98%
5mg
$ 106.00

Cayman Chemical
NSC 12 ≥98%
1mg
$ 25.00

Total 11 raw suppliers

Chemical Property of NSC-12

Chemical Property:

Boiling Point:521.8±45.0 °C(Predicted)
PKA:9.50±0.29(Predicted)
PSA：60.69000
Density:1.31±0.1 g/cm3(Predicted)
LogP:5.53300

Purity/Quality:

99%, ^*data from raw suppliers

NSC-12 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of NSC-12

There total 10 articles about NSC-12 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: (20S)-3β-benzoyloxy-21-(bis(trifluoromethyl)-hydroxymethyl)pregn-5-en-20-ol

: 102586-30-1
(20S)-21-(bis(trifluoromethyl)hydroxymethyl)pregn-5-en-3β,20-diol

Guidance literature:: With methanol; sodium; In tetrahydrofuran; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b02021

Reference yield: 95.0%

: (20R)-3β-benzoyloxy-21-(bis(trifluoromethyl)-hydroxymethyl)pregn-5-en-20-ol

: 102586-30-1
(20R)-21-(bis(trifluoromethyl)hydroxymethyl)pregn-5-en-3β,20-diol

Guidance literature:: With methanol; sodium; In tetrahydrofuran; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b02021

Reference yield:

: 1778-02-5
Pregnenolone acetate

: 102586-30-1
(20R)-21-(bis(trifluoromethyl)hydroxymethyl)pregn-5-en-3β,20-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium; methanol / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: pyridine / 24 h / 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.67 h / -78 °C / Inert atmosphere

3.2: 4 h / -78 - 20 °C

4.1: sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.1: sodium; methanol / tetrahydrofuran / 1 h / Inert atmosphere

With pyridine; methanol; sodium tetrahydroborate; sodium; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/acs.jmedchem.5b02021