9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione

Base Information

Chemical Name:9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
CAS No.:3519-82-2
Molecular Formula:C20H12O2
Molecular Weight:284.314
Hs Code.:
NSC Number:25996
DSSTox Substance ID:DTXSID70282457
Nikkaji Number:J269.917F,J937.909F
Wikidata:Q27164303
ChEMBL ID:CHEMBL1474701
Mol file:3519-82-2.mol

Synonyms:INCA-6;3519-82-2;NFAT Activation Inhibitor III;9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione;pentacyclo[6.6.6.02,7.09,14.015,20]icosa-2(7),4,9,11,13,15,17,19-octaene-3,6-dione;NSC 25996;Triptycene-1,4-quinone;9,10-o-Benzeno-9,10-dihydroanthracene-1,4-dione;9,10-Dihydro-9,10[1,2]-benzenoanthracene-1,4-dione;NSC25996;Probes1_000423;Probes2_000449;CBDivE_014338;SCHEMBL863946;SCHEMBL881196;CHEMBL1474701;CHEBI:92582;DTXSID70282457;HMS3268N19;HMS3413I17;HMS3677I17;LSM-2729;NSC-25996;STK949299;AKOS002186209;NCGC00092319-01;MS-24049;HY-108544;CS-0029115;J-019989;BRD-K33308633-001-01-6;Q27164303;Z57463854;9,10-Dihydro-9,10-[1,2]benzenoanthracene-13,16-dione;pentacyclo[6.6.6.0?,?.0?,??.0??,??]icosa-2(7),4,9,11,13,15,17,19-octaene-3,6-dione;pentacyclo[6.6.6.0~2,7~.0~9,14~.0~15,20~]icosa-2(7),4,9,11,13,15,17,19-octaene-3,6-dione (non-preferred name)

Suppliers and Price of 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
INCA-6
10mg
$ 389.00

TRC
INCA6
5mg
$ 200.00

TRC
INCA6
1mg
$ 60.00

Tocris
INCA-6 ≥98%(HPLC)
50
$ 615.00

Tocris
INCA-6 ≥98%(HPLC)
10
$ 147.00

Sigma-Aldrich
NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
5mg
$ 147.00

Cayman Chemical
NFAT Activation Inhibitor III ≥98%
50mg
$ 392.00

Cayman Chemical
NFAT Activation Inhibitor III ≥98%
10mg
$ 93.00

Cayman Chemical
NFAT Activation Inhibitor III ≥98%
5mg
$ 49.00

Cayman Chemical
NFAT Activation Inhibitor III ≥98%
25mg
$ 221.00

Total 10 raw suppliers

Chemical Property of 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione

Chemical Property:

Vapor Pressure:8.53E-09mmHg at 25°C
Boiling Point:464.2°C at 760 mmHg
Flash Point:172.6°C
PSA：34.14000
Density:1.38g/cm³
LogP:3.28200
Storage Temp.:Store at RT
Solubility.:Soluble in DMSO
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:284.083729621
Heavy Atom Count:22
Complexity:535

Purity/Quality:

99%, ^*data from raw suppliers

INCA-6 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C3C4=CC=CC=C4C(C2=C1)C5=C3C(=O)C=CC5=O
Description NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.
Uses INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs.

Technology Process of 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione

There total 2 articles about 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%