Fmoc-D-Asp-OMe

Base Information

• Chemical Name: Fmoc-D-Asp-OMe
• CAS No.: 368443-82-7
• Molecular Formula: C20H19NO6
• Molecular Weight: 369.37
• Mol file: 368443-82-7.mol

Synonyms:Fmoc-D-Asp-OMe;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-aspartic acid 1-methyl ester;N-Fmoc-D-aspartic acid 1-methyl ester

Chemical Property of Fmoc-D-Asp-OMe

Chemical Property:

• PSA: 105.42000
• LogP: 2.74580
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

FMOC-D-ASP-OME ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Fmoc-D-Asp-OMe

There total 2 articles about Fmoc-D-Asp-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

α-methyl γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartate (368443-81-6) → α-methyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartate (368443-82-7,145038-52-4)

Guidance literature:

With phenylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1039/b100401h

Reference yield:

N-alpha-(9-fluorenylmethyloxycarbonyl)-D-aspartic acid beta-allyl ester (177609-12-0) → α-methyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartate (368443-82-7,145038-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / ethyl acetate; diethyl ether / 1 h / 0 °C

2: 60 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂ / 2 h / 20 °C

With phenylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; ethyl acetate;

DOI:10.1039/b100401h

Reference yield:

α-methyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartate (368443-82-7,145038-52-4) → cyclo[(3R/S)-3-amino-3-phenylpropanoyl-(2R)-Glu-α-OMe-γ-Sar-(2R)-Asp-α-OMe-β-(2S)-Phe-]

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / DIPEA; BOP-Cl / CH₂Cl₂; dimethylformamide / 6 h / 0 °C

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/b100401h

upstream raw materials:

α-methyl γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)aspartate

N-alpha-(9-fluorenylmethyloxycarbonyl)-D-aspartic acid beta-allyl ester