Spizofurone

Base Information

Chemical Name:Spizofurone
CAS No.:72492-12-7
Molecular Formula:C₁₂H₁₀O₃
Molecular Weight:202.21
Hs Code.:
UNII:94F21T5G3C
DSSTox Substance ID:DTXSID20868144
Nikkaji Number:J20.578H
Wikidata:Q27271678
NCI Thesaurus Code:C73190
Metabolomics Workbench ID:144609
ChEMBL ID:CHEMBL18098
Mol file:72492-12-7.mol

Synonyms:5-acetylspiro(benzofuran-2(3H)-1'-cyclopropan)-3-one;AG-629;spizofurone

Suppliers and Price of Spizofurone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
SPIZOFURONE 95.00%
1G
$ 945.95

AHH
Spizofurone 98%
5g
$ 910.00

Total 27 raw suppliers

Chemical Property of Spizofurone

Chemical Property:

Vapor Pressure:1.73E-06mmHg at 25°C
Melting Point:150.0℃~155.0℃
Refractive Index:1.5080 (estimate)
Boiling Point:396.3 °C at 760 mmHg
Flash Point:180.6 °C
PSA：43.37000
Density:1.33 g/cm³
LogP:1.99690
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:202.062994177
Heavy Atom Count:15
Complexity:330

Purity/Quality:

99% ^*data from raw suppliers

SPIZOFURONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CC2=C(C=C1)OC3(C2=O)CC3
Description Spizofurone is an antiulcer agent that acts primarily by increasing mucus secretion and microcirculation in gastric mucosa and also by its inhibitory effect on acid secretion.

Technology Process of Spizofurone

There total 8 articles about Spizofurone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 72491-93-1
C₁₃H₁₀O₅

: 72492-12-7
5-acetylspiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one

Guidance literature:: With sodium chloride; In dimethyl sulfoxide; at 150 ℃; for 1.5h;
DOI:10.1248/cpb.32.3532

Reference yield: 67.0%

: 80901-29-7
methyl 5-acetyl-2-<(tetrahydro-2-oxo-3-furanyl)oxyl>benzoate

: 72492-12-7
5-acetylspiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one

: 94243-45-5
5,10'-diacetyl-5',6'-dihydrospirooxocino<3,2-b>benzofuran>-3-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium chloride; In N,N-dimethyl-formamide; at 150 ℃; for 2h;
DOI:10.1248/cpb.32.3373

Reference yield:

: 16475-90-4
estere metilico dell'acido 5-acetilsalicilico

: 72492-12-7
5-acetylspiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one

Guidance literature:: Multi-step reaction with 3 steps

2: 55 percent / Et₃N / acetic anhydride / Heating

3: 88 percent / NaCl / dimethylsulfoxide / 1.5 h / 150 °C

With triethylamine; sodium chloride; In acetic anhydride; dimethyl sulfoxide;
DOI:10.1248/cpb.32.3532