4-(Trifluoromethyl)-3-formylpyridine

Base Information

• Chemical Name: 4-(Trifluoromethyl)-3-formylpyridine
• CAS No.: 1083197-78-7
• Molecular Formula: C7H4F3NO
• Molecular Weight: 175.11
• Mol file: 1083197-78-7.mol

Synonyms:4-(TRIFLUOROMETHYL)NICOTINALDEHYDE;4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE;4-Trifluoromethyl-3-pyridine carbaldehyde;4-Trifluoromethyl-pyridine-3-carbaldehyde

Chemical Property of 4-(Trifluoromethyl)-3-formylpyridine

Chemical Property:

• PSA: 29.96000
• LogP: 1.91290

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Trifluoromethyl)-3-formylpyridine

There total 3 articles about 4-(Trifluoromethyl)-3-formylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methoxy-N-methyl-4-(trifluoromethyl)nicotinamide (323180-94-5) → 4-trifluoromethyl-3-pyridinecarboxaldehyde (1083197-78-7)

Guidance literature:

N-methoxy-N-methyl-4-(trifluoromethyl)nicotinamide; With diisopropylaluminium hydride; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Cooling with ice;

With water; rochelle salt; In diethyl ether;

Reference yield:

3-bromo-4-(trifluoromethyl)pyridine (936841-70-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-trifluoromethyl-3-pyridinecarboxaldehyde (1083197-78-7)

Guidance literature:

3-bromo-4-(trifluoromethyl)pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield:

4-(trifluoromethyl)nicotinic acid (158063-66-2) → 4-trifluoromethyl-3-pyridinecarboxaldehyde (1083197-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 5 h / 20 °C / Inert atmosphere

2: diisopropylaluminium hydride / hexane; tetrahydrofuran / 2 h / 0 °C / Cooling with ice

With diisopropylaluminium hydride; HATU; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;

upstream raw materials:

4-(trifluoromethyl)nicotinic acid

N-methoxy-N-methyl-4-(trifluoromethyl)nicotinamide

3-bromo-4-(trifluoromethyl)pyridine

N,N-dimethyl-formamide

Downstream raw materials:

(4-(trifluoromethyl)pyridin-3-yl)methanol

Refernces

• 1、 -. "TRIAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS". Page/Page column 39. . Retrieved 2013/04/10.