4-(Trifluoromethyl)-3-formylpyridine

Base Information

Chemical Name:4-(Trifluoromethyl)-3-formylpyridine
CAS No.:1083197-78-7
Molecular Formula:C7H4F3NO
Molecular Weight:175.11
Hs Code.:
Mol file:1083197-78-7.mol

Synonyms:4-(TRIFLUOROMETHYL)NICOTINALDEHYDE;4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE;4-Trifluoromethyl-3-pyridine carbaldehyde;4-Trifluoromethyl-pyridine-3-carbaldehyde

Suppliers and Price of 4-(Trifluoromethyl)-3-formylpyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 18 raw suppliers

Chemical Property of 4-(Trifluoromethyl)-3-formylpyridine

Chemical Property:

PSA：29.96000
LogP:1.91290

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-(Trifluoromethyl)-3-formylpyridine

There total 3 articles about 4-(Trifluoromethyl)-3-formylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 323180-94-5
N-methoxy-N-methyl-4-(trifluoromethyl)nicotinamide

: 1083197-78-7
4-trifluoromethyl-3-pyridinecarboxaldehyde

Guidance literature:: N-methoxy-N-methyl-4-(trifluoromethyl)nicotinamide; With diisopropylaluminium hydride; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Cooling with ice;

With water; rochelle salt; In diethyl ether;

Reference yield:

: 936841-70-2
3-bromo-4-(trifluoromethyl)pyridine

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1083197-78-7
4-trifluoromethyl-3-pyridinecarboxaldehyde

Guidance literature:: 3-bromo-4-(trifluoromethyl)pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield:

: 158063-66-2
4-(trifluoromethyl)nicotinic acid

: 1083197-78-7
4-trifluoromethyl-3-pyridinecarboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 5 h / 20 °C / Inert atmosphere

2: diisopropylaluminium hydride / hexane; tetrahydrofuran / 2 h / 0 °C / Cooling with ice

With diisopropylaluminium hydride; HATU; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;