2,4-dibromo-1-(trifluoromethoxy)benzene

Base Information

• Chemical Name: 2,4-dibromo-1-(trifluoromethoxy)benzene
• CAS No.: 1840-97-7
• Molecular Formula: C7H3Br2F3O
• Molecular Weight: 319.903
• Mol file: 1840-97-7.mol

Synonyms:2,4-dibromo-1-(trifluoromethoxy)benzene

Chemical Property of 2,4-dibromo-1-(trifluoromethoxy)benzene

Chemical Property:

• PSA: 9.23000
• LogP: 4.11020
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dibromo-1-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dibromo-1-(trifluoromethoxy)benzene

There total 3 articles about 2,4-dibromo-1-(trifluoromethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-bromo-4-(trifluoromethoxy)aniline (191602-54-7) → Trifluormethyl-<4-brom-phenyl>-aether (1840-97-7)

Guidance literature:

3-bromo-4-(trifluoromethoxy)aniline; With hydrogen bromide; In water; at 70 - 80 ℃; for 0.5h; Large scale;

With copper(I) bromide; sodium nitrite; In water; at 40 - 50 ℃; for 1h; Large scale;

Reference yield:

4-(trifluoromethoxy)aniline (461-82-5) → Trifluormethyl-<4-brom-phenyl>-aether (1840-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; N-Bromosuccinimide / 1 h / 5 - 15 °C / Large scale

2.1: hydrogen bromide / water / 0.5 h / 70 - 80 °C / Large scale

2.2: 1 h / 40 - 50 °C / Large scale

With N-Bromosuccinimide; sulfuric acid; hydrogen bromide; In water;

Reference yield:

→ Trifluormethyl-<4-brom-phenyl>-aether (1840-97-7)

Guidance literature:

aus 2,4-Dibrom-phenol, 1.) COF2, Druckgefaess, 1h, 100grad, 2.) 2-3h ca. 140grad, 3.) SF4, Druckgefaess, 2h 100grad, 4.) 2h ca. 150grad, 5.) 2h ca. 175grad;

upstream raw materials:

4-(trifluoromethoxy)aniline

3-bromo-4-(trifluoromethoxy)aniline

Downstream raw materials:

C₉H₃F₃N₂O

Refernces