Mitoquinone mesylate

Base Information

• Chemical Name: Mitoquinone mesylate
• CAS No.: 845959-50-4
• Molecular Formula: CH₃O₃S*C₃₇H₄₄O₄P
• Molecular Weight: 678.827
• UNII: 6E01CG547T
• ChEMBL ID: CHEMBL4074884
• DSSTox Substance ID: DTXSID00233573
• Wikidata: Q15425822
• Wikipedia: Mitoquinone_mesylate
• Mol file: 845959-50-4.mol

Synonyms:(10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl)triphenyl phosphonium;10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide;Mito-Q;MitoQ;mitoquinone;mitoquinone bromide;mitoquinone cation;mitoquinone ion;mitoquinone mesylate;mitoquinone methanesulfonate;phosphonium, (10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl)triphenyl-, methanesulfonate (1:1)

Chemical Property of Mitoquinone mesylate

Chemical Property:

• PSA: 131.77000
• LogP: 7.70630
• Storage Temp.: -20°C
• Solubility.: Soluble in DMSO.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 16
• Exact Mass: 678.27801201
• Heavy Atom Count: 47
• Complexity: 965

Purity/Quality:

99%, ^*data from raw suppliers

MitoquinoneMesylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.CS(=O)(=O)[O-]
• Recent ClinicalTrials: MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
• Recent EU Clinical Trials: A Double-blind Randomised Placebo-controlled Multicentre Study of 40mg MitoQ and Placebo for the Treatment of Participants with Raised Liver Enzymes due to Non-Alcoholic Fatty Liver Disease (NAFLD)
• Description: Mitoquinone mesylate (845959-50-4) is a mitochondria-targeted antioxidant.? Displays cardio- and neuroprotective effects.1 Displays beneficial effects in mouse models of Alzheimer’s disease.2,3 Protects pancreatic β-cells against oxidative stress and improves insulin secretion.4 Inhibits respiratory syncytial virus (RSV) production via lowering of mitochondrial ROS levels.5 Cell permeable.
• Uses: Mitoquinone Mesylate is used in the transport and metabolism of some cationic ubiquinone antioxidants.

Technology Process of Mitoquinone mesylate

There total 1 articles about Mitoquinone mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

[10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl]triphenylphosphonium, monomethanesulfonate → [10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenylphosphonium methanesulfonate (845959-50-4)

Guidance literature:

With oxygen; Nitrogen dioxide; In dichloromethane; at 20 ℃; for 4 - 8h;

Refernces