1-BOC-4-(PYRIDIN-3-YLAMINO)PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-(PYRIDIN-3-YLAMINO)PIPERIDINE
• CAS No.: 301225-52-5
• Molecular Formula: C₁₅H₂₃N₃O₂
• Molecular Weight: 277.367
• Mol file: 301225-52-5.mol

Synonyms:1-BOC-4-(PYRIDIN-3-YLAMINO)PIPERIDINE;tert-butyl 4-(pyridin-3-ylamino)piperidine-1-carboxylate

Chemical Property of 1-BOC-4-(PYRIDIN-3-YLAMINO)PIPERIDINE

Chemical Property:

• Boiling Point: 418.4±35.0 °C(Predicted)
• PKA: 5.85±0.11(Predicted)
• PSA: 54.46000
• Density: 1.142±0.06 g/cm3(Predicted)
• LogP: 2.90390

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(PYRIDIN-3-YLAMINO)PIPERIDINE

There total 6 articles about 1-BOC-4-(PYRIDIN-3-YLAMINO)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

pyridin-3-ylamine (462-08-8) + tert-butyl 4-oxopyridine-1-carboxylate (332940-69-9) → tert-butyl 4-(pyridin-3-ylamino)piperidine-1-carboxylate (301225-52-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 50 ℃; Reflux;

Reference yield: 64.0%

pyridin-3-ylamine (462-08-8) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-(pyridin-3-ylamino)piperidine-1-carboxylate (301225-52-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; for 20h; Reflux;

DOI:10.1021/jm401610c

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → tert-butyl 4-(pyridin-3-ylamino)piperidine-1-carboxylate (301225-52-5)

Guidance literature:

With sodium t-butanolate; In toluene;

upstream raw materials:

1-(tert-butoxycarbonyl)-4-aminopiperidine

pyridin-3-ylamine

N-tert-butyloxycarbonylpiperidin-4-one

4-benzylamino-piperidine-1-carboxylic acid tert-butyl ester