5-Phenylnaphthalene-1-carboxylic acid

Base Information

• Chemical Name: 5-Phenylnaphthalene-1-carboxylic acid
• CAS No.: 179473-63-3
• Molecular Formula: C17H12O2
• Molecular Weight: 248.281
• Mol file: 179473-63-3.mol

Synonyms:5-Phenylnaphthalene-1-carboxylic acid

Chemical Property of 5-Phenylnaphthalene-1-carboxylic acid

Chemical Property:

• PSA: 37.30000
• LogP: 4.20500

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Phenylnaphthalene-1-carboxylic acid

There total 3 articles about 5-Phenylnaphthalene-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-bromo-1-naphthalenecarboxylic acid (16726-67-3) + phenylboronic acid (98-80-6) → 5-phenyl-1-naphthoic acid (179473-63-3)

Guidance literature:

With sodium phosphate dodecahydrate; 5%-palladium/activated carbon; In isopropyl alcohol; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

5-bromo-1-naphthalenecarboxylic acid (16726-67-3) → 5-phenyl-1-naphthoic acid (179473-63-3)

Guidance literature:

With nitrogen;

Reference yield:

1-naphthalenecarboxylic acid (86-55-5) → 5-phenyl-1-naphthoic acid (179473-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / 40 h / 70 - 120 °C

2: sodium phosphate dodecahydrate; 5%-palladium/activated carbon / isopropyl alcohol / 12 h / 20 °C / Inert atmosphere

With sodium phosphate dodecahydrate; 5%-palladium/activated carbon; bromine; acetic acid; In isopropyl alcohol;

upstream raw materials:

5-bromo-1-naphthalenecarboxylic acid

1-naphthalenecarboxylic acid

phenylboronic acid

Refernces

• 1、 -. "2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents". . . Retrieved 2008/06/13.