2-lodo-5-Methylbenzaldehyde

Base Information

• Chemical Name: 2-lodo-5-Methylbenzaldehyde
• CAS No.: 1106813-84-6
• Molecular Formula: C₈H₇IO
• Molecular Weight: 246.047
• Mol file: 1106813-84-6.mol

Synonyms:2-lodo-5-Methylbenzaldehyde;2-iodo-5-Methylbenzaldehyde

Chemical Property of 2-lodo-5-Methylbenzaldehyde

Chemical Property:

• Boiling Point: 276.1±28.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.764±0.06 g/cm3(Predicted)
• LogP: 2.41210

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Iodo-5-methylbenzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-lodo-5-Methylbenzaldehyde

There total 5 articles about 2-lodo-5-Methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2-iodo-5-methyl-phenyl)-methanol → 2-iodo-5-methylbenzaldehyde (1106813-84-6)

Guidance literature:

With dipyridinium dichromate; silica gel; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03577

Reference yield: 56.0%

m-tolyl aldehyde (620-23-5) → 2-iodo-5-methylbenzaldehyde (1106813-84-6)

Guidance literature:

With N-iodo-succinimide; 2,5-bis(trifluoromethyl)aniline; palladium diacetate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 60 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.1c03491

Reference yield:

2-iodoyl-5-methylbenzoic acid (52548-14-8) → 2-iodo-5-methylbenzaldehyde (1106813-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C

2: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 0 - 20 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; silica gel; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3cc40577j

upstream raw materials:

2-iodoyl-5-methylbenzoic acid

2-Amino-5-methylbenzoic acid

m-tolyl aldehyde

Refernces

• 1、 Whyte, Andrew,Olson, Maxwell E.,Lautens, Mark. "Palladium-Catalyzed, Norbornene-Mediated, ortho-Amination ipso-Amidation: Sequential C-N Bond Formation". supporting information. p. 345 - 348. Retrieved 2018/01/27.
• 2、 Tang, Hai-Jun,Zhang, Yu-Feng,Jiang, Yi-Wen,Feng, Chao. "F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes". supporting information. p. 5190 - 5193. Retrieved 2018/09/12.