1,2,3,4-Tetrahydro-2,3-dimethylisoquinoline

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-2,3-dimethylisoquinoline
• CAS No.: 54365-72-9
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.247
• Hs Code.: 2933499090
• Mol file: 54365-72-9.mol

Synonyms:1,2,3,4-Tetrahydro-2,3-dimethylisoquinoline

Chemical Property of 1,2,3,4-Tetrahydro-2,3-dimethylisoquinoline

Chemical Property:

• PSA: 3.24000
• LogP: 2.00090

Purity/Quality:

2,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-Tetrahydro-2,3-dimethylisoquinoline

There total 4 articles about 1,2,3,4-Tetrahydro-2,3-dimethylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,3-dimethylisoquinolinium iodide (32431-36-0) → 2,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline (54365-72-9)

Guidance literature:

With indium; ammonium chloride; In ethanol; Heating;

DOI:10.1039/b101712h

Reference yield:

3-methylisoquinoline (1125-80-0) → 2,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline (54365-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / HCOOH; Et₃N / [Cp*RhCl₂]2 / CH₂Cl₂ / 24 h / 40 °C

With formic acid; triethylamine; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In dichloromethane;

DOI:10.1055/s-2006-949606

Reference yield:

2,3-dimethyl-isoquinolinium; bromide → 2,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline (54365-72-9)

Guidance literature:

With platinum; Hydrogenation;

DOI:10.1021/ja01618a033

upstream raw materials:

2,3-dimethylisoquinolinium iodide

3-methylisoquinoline

Refernces

• 1、 Pitts,Harrison,Moody. "Indium metal as a reducing agent in organic synthesis". . p. 955 - 977. Retrieved 2007/10/03.