4-METHYL-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-METHYL-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 908244-98-4
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Hs Code.: 2933399090
• Mol file: 908244-98-4.mol

Synonyms:4-METHYL-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER;Methyl 4-Methylnipecotate;Methyl 4-Methylpiperidine-3-carboxylate hcl

Chemical Property of 4-METHYL-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 38.33000
• LogP: 1.53580

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-Methylnipecotate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-Methylnipecotate, is an intermediate used for the synthesis of various piperdine derivatives, acting as inhibitors and theraputic agents.

Technology Process of 4-METHYL-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER

There total 4 articles about 4-METHYL-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methylnicotinic acid methyl ester (33402-75-4) → methyl 4-methylpiperidine-3-carboxylate (908244-98-4)

Guidance literature:

With hydrogenchloride; hydrogen; 1% Pd/C; In methanol; water; at 80 ℃; for 16h; under 3102.97 Torr; Inert atmosphere;

Reference yield:

3-Bromo-4-methylpyridin (3430-22-6) → methyl 4-methylpiperidine-3-carboxylate (908244-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 140 °C / 22502.3 Torr / Autoclave

2: platinum(IV) oxide; hydrogen / acetic acid / 168 h / 50 °C

With platinum(IV) oxide; 1,1'-bis-(diphenylphosphino)ferrocene; hydrogen; palladium diacetate; triethylamine; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

4-methylnicotinic acid (3222-50-2) → methyl 4-methylpiperidine-3-carboxylate (908244-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / 16 h / Reflux

2: hydrogen; acetic acid / platinum(IV) oxide / 16 h / 45 °C / Inert atmosphere

With oxalyl dichloride; hydrogen; acetic acid; platinum(IV) oxide;

upstream raw materials:

4-methylnicotinic acid methyl ester

4-methylnicotinic acid

3-Bromo-4-methylpyridin

Downstream raw materials:

1-(tert-butyl) 3-methyl 4-methylpiperidine-1,3-dicarboxylate

1-(tert-butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid

trans-racemic tert-butyl 3-amino-4-methylpiperidine-1-carboxylate

trans 1-(tert-butoxycarbonyl)-4-methylpiperidine-3-carboxylic acid