5H-Oxazolo[3,4-a]oxireno[e]azocin-5-one, octahydro-8,9-dihydroxy-, (1aS,7aR,8R,9S,9aR)- (9CI)

Base Information

Chemical Name:5H-Oxazolo[3,4-a]oxireno[e]azocin-5-one, octahydro-8,9-dihydroxy-, (1aS,7aR,8R,9S,9aR)- (9CI)
CAS No.:317855-36-0
Molecular Formula:C9H13NO5
Molecular Weight:215.2
Hs Code.:
Mol file:317855-36-0.mol

Synonyms:5H-Oxazolo[3,4-a]oxireno[e]azocin-5-one, octahydro-8,9-dihydroxy-, (1aS,7aR,8R,9S,9aR)- (9CI)

Suppliers and Price of 5H-Oxazolo[3,4-a]oxireno[e]azocin-5-one, octahydro-8,9-dihydroxy-, (1aS,7aR,8R,9S,9aR)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5H-Oxazolo[3,4-a]oxireno[e]azocin-5-one, octahydro-8,9-dihydroxy-, (1aS,7aR,8R,9S,9aR)- (9CI)

Chemical Property:

Melting Point:92-96 °C
Boiling Point:523.6±50.0 °C(Predicted)
PKA:13.52±0.40(Predicted)
Density:1.58±0.1 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5H-Oxazolo[3,4-a]oxireno[e]azocin-5-one, octahydro-8,9-dihydroxy-, (1aS,7aR,8R,9S,9aR)- (9CI)

There total 3 articles about 5H-Oxazolo[3,4-a]oxireno[e]azocin-5-one, octahydro-8,9-dihydroxy-, (1aS,7aR,8R,9S,9aR)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: (9R,10R,10aR)-9,10-dihydroxy-1,5,6,9,10,10a-hexahydro[1,3]oxazolo[3,4-a]azocin-3-one

: 317855-36-0
(1aS,7aR,8R,9S,9aR)-8,9-dihydroxyoctahydro[1,3]oxazolo[3,4-a]oxireno[2,3-e]azocin-5-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at 20 ℃; for 7h;
DOI:10.1021/jo0012748

Reference yield:

: 212609-03-5
(4R)-3-(3-butenyl)-4-[(4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-1,3-oxazolidin-2-one

: 317855-36-0
(1aS,7aR,8R,9S,9aR)-8,9-dihydroxyoctahydro[1,3]oxazolo[3,4-a]oxireno[2,3-e]azocin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Cl₂(Cy₃P)2RuCHPh / CH₂Cl₂ / 5 h / 20 °C

2: 99 percent / conc. HBr / acetonitrile / 1 h / 20 °C

3: 62 percent / m-chloroperoxybenzoic acid / tetrahydrofuran / 7 h / 20 °C

With hydrogen bromide; 3-chloro-benzenecarboperoxoic acid; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo0012748

Reference yield:

: (3aR,11aR,11bR)-2,2-dimethyl-3a,6,7,11,11a,11b-hexahydro[1,3]dioxolo[4,5-c][1,3]oxazolo[3,4-a]azocin-9-one

: 317855-36-0
(1aS,7aR,8R,9S,9aR)-8,9-dihydroxyoctahydro[1,3]oxazolo[3,4-a]oxireno[2,3-e]azocin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / conc. HBr / acetonitrile / 1 h / 20 °C

2: 62 percent / m-chloroperoxybenzoic acid / tetrahydrofuran / 7 h / 20 °C

With hydrogen bromide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo0012748