1-chloro-4-[3-[[2-(4-ethoxyphenyl)-3,3,3-trifluoro-propoxy]methyl]phen oxy]benzene

Base Information

Chemical Name:1-chloro-4-[3-[[2-(4-ethoxyphenyl)-3,3,3-trifluoro-propoxy]methyl]phen oxy]benzene
CAS No.:118753-05-2
Molecular Formula:C₂₄H₂₂ClF₃O₃
Molecular Weight:450.885
Hs Code.:
Mol file:118753-05-2.mol

Synonyms:1-chloro-4-[3-[[2-(4-ethoxyphenyl)-3,3,3-trifluoro-propoxy]methyl]phen oxy]benzene

Suppliers and Price of 1-chloro-4-[3-[[2-(4-ethoxyphenyl)-3,3,3-trifluoro-propoxy]methyl]phen oxy]benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-chloro-4-[3-[[2-(4-ethoxyphenyl)-3,3,3-trifluoro-propoxy]methyl]phen oxy]benzene

Chemical Property:

Vapor Pressure:5.49E-09mmHg at 25°C
Boiling Point:482.1°C at 760 mmHg
Flash Point:245.4°C
Density:1.243g/cm³

Purity/Quality:

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Technology Process of 1-chloro-4-[3-[[2-(4-ethoxyphenyl)-3,3,3-trifluoro-propoxy]methyl]phen oxy]benzene

There total 10 articles about 1-chloro-4-[3-[[2-(4-ethoxyphenyl)-3,3,3-trifluoro-propoxy]methyl]phen oxy]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1-(bromomethyl)-3-(4-chlorophenoxy)benzene

: 2-(4-Ethoxy-phenyl)-3,3,3-trifluoro-propionic acid

: 107713-58-6,118753-05-2
3-(4-chlorophenoxy)benzyl (RS)-2-(4-ethoxyphenyl)-3,3,3-trifluoropropyl ether

Guidance literature:: 2-(4-Ethoxy-phenyl)-3,3,3-trifluoro-propionic acid; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

1-(bromomethyl)-3-(4-chlorophenoxy)benzene; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 10h;
DOI:10.1021/ja307058c

Reference yield:

: tetra(n-butyl)ammonium hydrogen sulfate

: 117467-36-4
(RS)-1,1,1-trifluoro-2-(4-ethoxyphenyl)propan-3-ol

: 72714-63-7
3-(4'-chlorophenoxy)-benzyl alcohol

: 107713-58-6,118753-05-2
3-(4-chlorophenoxy)benzyl (RS)-2-(4-ethoxyphenyl)-3,3,3-trifluoropropyl ether

Guidance literature:: With sodium hydroxide; triethylamine; In diethyl ether; dichloromethane;

Reference yield:

: ethyl α-diazo-(4'-ethoxy-phenyl)-acetate

: 107713-58-6,118753-05-2
3-(4-chlorophenoxy)benzyl (RS)-2-(4-ethoxyphenyl)-3,3,3-trifluoropropyl ether

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride; copper(l) iodide / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 20 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 - 20 °C / Inert atmosphere

3.2: 10 h / 0 - 20 °C

With copper(l) iodide; lithium aluminium tetrahydride; sodium hydride; cesium fluoride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja307058c