Chemical Property of IMR-1
Chemical Property:
- PSA：131.25000
- LogP:2.45470
- Storage Temp.:2-8°C(protect from light)
- Solubility.:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 9 mg/ml with warming).
- Purity/Quality:
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99%, *data from raw suppliers
IMR-1 >98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
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Description
Inhibitor of Mastermind Recruitment-1 (IMR-1, 310456-65-6) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription.1?IC50=26 μM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethyl ester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 μM (in vitro?assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
