ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-2-CYANOACETATE

Base Information

• Chemical Name: ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-2-CYANOACETATE
• CAS No.: 865370-16-7
• Molecular Formula: C10H16N2O4
• Molecular Weight: 228.248
• Mol file: 865370-16-7.mol

Synonyms:ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-2-CYANOACETATE;tert-butyl(ethoxycarbonyl)(cyano)methylcarbamate;N-Bocamino-Cyano-Acetic Acid Ethyl Ester

Chemical Property of ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-2-CYANOACETATE

Chemical Property:

• PSA: 91.91000
• LogP: 1.17078
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-Bocamino-cyano-aceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-2-CYANOACETATE

There total 8 articles about ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)-2-CYANOACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-cyano-2-ethoxy-2-oxoethanaminium 4-methylbenzenesulfonate (37842-58-3) → tert-butoxycarbonylamino-cyano-acetic acid ethyl ester (865370-16-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 100 ℃; for 5h;

DOI:10.1002/anie.200800329

Reference yield: 83.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl-2-aminocyano acetate (32683-02-6) → tert-butoxycarbonylamino-cyano-acetic acid ethyl ester (865370-16-7)

Guidance literature:

DOI:10.1016/j.bmcl.2011.10.088

Reference yield: 33.0%

ethyl 2-cyanoacetate (105-56-6) + oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester (462100-44-3) → tert-butoxycarbonylamino-cyano-acetic acid ethyl ester (865370-16-7)

Guidance literature:

ethyl 2-cyanoacetate; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1016/j.tet.2005.06.085

upstream raw materials:

ethyl 2-cyanoacetate

oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester

di-tert-butyl dicarbonate

1-cyano-2-ethoxy-2-oxoethanaminium 4-methylbenzenesulfonate

Downstream raw materials:

ethyl 2-(tert-butoxycarbonylamino)-2-cyano-3-[(-)-menthyloxycarbonyl]propionate

C₂₄H₃₈N₂O₄

C₂₃H₂₇ClN₂O₄

C₂₅H₃₂N₂O₄

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