Technology Process of DIFO
There total 6 articles about DIFO which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
1,4-dioxane; water;
at 55 ℃;
for 7h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: caesium carbonate / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
1.2: 6.25 h / 0 - 20 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24.33 h / 0 - 20 °C / Inert atmosphere
3.1: hydrogen; palladium on activated charcoal / methanol / 1.5 h
4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere
4.2: 1.5 h / -78 - 20 °C
5.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
6.1: lithium hydroxide / 1,4-dioxane; water / 7 h / 55 °C
With
n-butyllithium; palladium on activated charcoal; hydrogen; potassium hexamethylsilazane; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24.33 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogen; palladium on activated charcoal / methanol / 1.5 h
3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.92 h / -78 °C / Inert atmosphere
3.2: 1.5 h / -78 - 20 °C
4.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1.5 h / -78 - 20 °C / Inert atmosphere
5.1: lithium hydroxide / 1,4-dioxane; water / 7 h / 55 °C
With
n-butyllithium; palladium on activated charcoal; hydrogen; potassium hexamethylsilazane; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water;
