(R)-2-AMINO-3-METHOXY-1-PROPANOL

Base Information

• Chemical Name: (R)-2-AMINO-3-METHOXY-1-PROPANOL
• CAS No.: 148278-96-0
• Molecular Weight: 105.14
• Mol file: 148278-96-0.mol

Synonyms:(R)-2-AMINO-3-METHOXY-1-PROPANOL

Chemical Property of (R)-2-AMINO-3-METHOXY-1-PROPANOL

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-AMINO-3-METHOXY-1-PROPANOL

There total 6 articles about (R)-2-AMINO-3-METHOXY-1-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-tert-butyl 1-hydroxy-3-methoxy propan-2-yl carbamate (183793-49-9,721927-59-9) → (R)-2-amino-3-methoxy-propan-1-ol (148278-96-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1016/j.tetlet.2013.09.084

Reference yield:

DL-3-methoxy-alanine (4219-94-7,19794-53-7,32620-11-4,86118-11-8) → (R)-2-amino-3-methoxy-propan-1-ol (148278-96-0)

Guidance literature:

With borane-THF; at 20 - 30 ℃; for 1h;

Reference yield:

(R)-((2-azido-3-methoxypropoxy)methyl)benzene (1334286-16-6) → (S)-2-amino-3-methoxy-propan-1-ol (148278-96-0)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2011.07.024

upstream raw materials:

(R)-tert-butyl 1-hydroxy-3-methoxy propan-2-yl carbamate

(S)-4-methoxymethyl-2-phenyl-oxazoline

DL-3-methoxy-alanine

(R)-((2-azido-3-methoxypropoxy)methyl)benzene

Downstream raw materials:

3-methoxy-2-((2-((2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)pyrido[3,4-d]pyrimidin-8-yl)amino)propan-1-ol

Refernces

• 1、 Petitbois, Julie G.,Casalme, Loida O.,Lopez, Julius Adam V.,Alarif, Walied M.,Abdel-Lateff, Ahmed,Al-Lihaibi, Sultan S.,Yoshimura, Erina,Nogata, Yasuyuki,Umezawa, Taiki,Matsuda, Fuyuhiko,Okino, Tatsufumi. "Serinolamides and Lyngbyabellins from an Okeania sp. Cyanobacterium Collected from the Red Sea". . p. 2708 - 2715. Retrieved 2017/11/06.
• 2、 Muthukrishnan,Mujahid,Sasikumar,Mujumdar. "First asymmetric synthesis of the antiepileptic drug Lacosamide (Vimpat) based on a hydrolytic kinetic resolution strategy". scheme or table. p. 1353 - 1357. Retrieved 2011/11/29.