2-Fluoro-6-hydroxybenzamide

Base Information

Chemical Name:2-Fluoro-6-hydroxybenzamide
CAS No.:160748-95-8
Molecular Formula:C₇H₆FNO₂
Molecular Weight:155.129
Hs Code.:
European Community (EC) Number:829-519-8
DSSTox Substance ID:DTXSID00570197
Wikidata:Q82457573
Mol file:160748-95-8.mol

Synonyms:2-FLUORO-6-HYDROXYBENZAMIDE;160748-95-8;BENZAMIDE, 2-FLUORO-6-HYDROXY-;Benzamide, 2-fluoro-6-hydroxy- (9CI);SCHEMBL8174459;DTXSID00570197;DHNYGSKZXMZJIA-UHFFFAOYSA-N;AKOS017516473;MB25665;AS-80494;CS-0173671;EN300-135661;Z1255367443

Suppliers and Price of 2-Fluoro-6-hydroxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-fluoro-6-hydroxybenzamide
10mg
$ 65.00

Alichem
2-Fluoro-6-hydroxybenzamide
250mg
$ 504.00

Alichem
2-Fluoro-6-hydroxybenzamide
500mg
$ 839.45

Alichem
2-Fluoro-6-hydroxybenzamide
1g
$ 1504.90

AK Scientific
2-Fluoro-6-hydroxybenzamide
500mg
$ 988.00

AK Scientific
2-Fluoro-6-hydroxybenzamide
250mg
$ 658.00

Total 6 raw suppliers

Chemical Property of 2-Fluoro-6-hydroxybenzamide

Chemical Property:

Boiling Point:272.5±30.0 °C(Predicted)
PKA:7.37±0.10(Predicted)
PSA：64.31000
Density:1.400±0.06 g/cm3(Predicted)
LogP:1.51440
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:155.03825660
Heavy Atom Count:11
Complexity:163

Purity/Quality:

98% ^*data from raw suppliers

2-fluoro-6-hydroxybenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C(=C1)F)C(=O)N)O

Technology Process of 2-Fluoro-6-hydroxybenzamide

There total 1 articles about 2-Fluoro-6-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 160748-95-8
2-fluoro-6-hydroxybenzamide

Guidance literature:

Reference yield:

: 160748-95-8
2-fluoro-6-hydroxybenzamide

: 1436710-90-5
C₁₉H₁₅FN₄O

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 16 h / Dean-Stark; Reflux; Inert atmosphere

2: trichlorophosphate; phosphorus pentachloride / 3 h / 50 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

4: acetic acid; zinc / 3 h / 20 - 25 °C / Inert atmosphere

5: bis(triphenylphosphine)palladium(II)-chloride; sodium carbonate / 1,2-dimethoxyethane; water / 2 h / 80 °C / Inert atmosphere

With bis(triphenylphosphine)palladium(II)-chloride; phosphorus pentachloride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; trichlorophosphate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm3011349

Reference yield:

: 160748-95-8
2-fluoro-6-hydroxybenzamide

: 2-(3-bromophenyl)-4-chloro-5-fluoro-2-methyl-2H-benzo[e][1,3]oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 16 h / Dean-Stark; Reflux; Inert atmosphere

2: trichlorophosphate; phosphorus pentachloride / 3 h / 50 °C / Inert atmosphere

With phosphorus pentachloride; toluene-4-sulfonic acid; trichlorophosphate; In toluene;
DOI:10.1021/jm3011349