(13β,14β)-4,5α-Epoxy-3-methoxy-17-methylhasubanan-6α-ol

Base Information

• Chemical Name: (13β,14β)-4,5α-Epoxy-3-methoxy-17-methylhasubanan-6α-ol
• CAS No.: 4892-49-3
• Molecular Weight: 301.38
• Mol file: 4892-49-3.mol

Synonyms:(13β,14β)-4,5α-Epoxy-3-methoxy-17-methylhasubanan-6α-ol;Dihydroindolinocodeine

Chemical Property of (13β,14β)-4,5α-Epoxy-3-methoxy-17-methylhasubanan-6α-ol

Chemical Property:

• Boiling Point: 464.5±45.0 °C(Predicted)
• PKA: 14.09±0.20(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (13β,14β)-4,5α-Epoxy-3-methoxy-17-methylhasubanan-6α-ol

There total 7 articles about (13β,14β)-4,5α-Epoxy-3-methoxy-17-methylhasubanan-6α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ent-4,5β-epoxy-3-methoxy-17-methyl-hasuban-7-en-6β-ol; hydrochloride (898-41-9) → ent-4,5β-epoxy-3-methoxy-17-methyl-hasubanan-6β-ol (4892-49-3)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; for 3h; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.13.1092

Reference yield:

9,10-Didehydroindolinocodeinon (33633-04-4) → ent-4,5β-epoxy-3-methoxy-17-methyl-hasubanan-6β-ol (4892-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol

2: H₂ / Pd-C / methanol

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1007/BF00911309

Reference yield:

ent-4,5β-epoxy-3-methoxy-17-methyl-hasubana-7,9-dien-6β-ol (52517-11-0) → ent-4,5β-epoxy-3-methoxy-17-methyl-hasubanan-6β-ol (4892-49-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1007/BF00911309

upstream raw materials:

ent-4,5β-epoxy-3-methoxy-17-methyl-hasuban-7-en-6-one

ent-4,5β-epoxy-3-methoxy-17-methyl-hasuban-7-en-6β-ol; hydrochloride

ent-4,5β-epoxy-3-methoxy-17-methyl-hasubana-7,9-dien-6β-ol

ent-4,5β-epoxy-3-methoxy-17-methyl-hasuban-7-en-6β-ol