2-PYRIDINEPROPANOIC ACID, 5-BROMO-.ALPHA.-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-, (.ALPHA.S)-

Base Information

Chemical Name:2-PYRIDINEPROPANOIC ACID, 5-BROMO-.ALPHA.-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-, (.ALPHA.S)-
CAS No.:282734-37-6
Molecular Formula:C₂₃H₁₉BrN₂O₄
Molecular Weight:467.319
Hs Code.:
Mol file:282734-37-6.mol

Synonyms:2-PYRIDINEPROPANOIC ACID, 5-BROMO-.ALPHA.-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-, (.ALPHA.S)-;(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(5-bromopyridin-2-yl)propanoic acid;N2-Fmoc-3-(5-bromopyrid-2-yl)-L-alanine;REF DUPL: N2-Fmoc-3-(5-bromopyrid-2-yl)-L-alanine

Suppliers and Price of 2-PYRIDINEPROPANOIC ACID, 5-BROMO-.ALPHA.-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-, (.ALPHA.S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(S)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-3-(5-BROMOPYRIDIN-2-YL)PROPANOIC ACID 95.00%
5MG
$ 498.73

Total 2 raw suppliers

Chemical Property of 2-PYRIDINEPROPANOIC ACID, 5-BROMO-.ALPHA.-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-, (.ALPHA.S)-

Chemical Property:

PSA：88.52000
LogP:4.76940

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-(((9H-FLUOREN-9-YL)METHOXY)CARBONYLAMINO)-3-(5-BROMOPYRIDIN-2-YL)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-PYRIDINEPROPANOIC ACID, 5-BROMO-.ALPHA.-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-, (.ALPHA.S)-

There total 6 articles about 2-PYRIDINEPROPANOIC ACID, 5-BROMO-.ALPHA.-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO]-, (.ALPHA.S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 282734-36-5
(2S)-(N-fluorenylmethoxycarbonylamino)-3-(5'-bromopyrid-2'-yl)propionic acid methyl ester

: 282734-37-6
(2S)-2-(fluorenylmethoxycarbonylamino)-3-(5'-bromo-2'-pyridyl)propionic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1039/a910179i

Reference yield:

: 624-28-2
2,5-dibromopyridine

: 282734-37-6
(2S)-2-(fluorenylmethoxycarbonylamino)-3-(5'-bromo-2'-pyridyl)propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: Zn; 1,2-dibromoethane; Me₃SiCl / dimethylformamide / 2 h / 35 °C

1.2: 60 percent / Pd(PPh₃)2Cl₂ / dimethylformamide

2.1: 85 percent / aq. LiOH / tetrahydrofuran / 20 °C

With lithium hydroxide; chloro-trimethyl-silane; ethylene dibromide; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/b308750f

Reference yield:

: 82911-78-2
N-[(9-fluorenylmethoxy)carbonyl]-L-serine methyl ester

: 282734-37-6
(2S)-2-(fluorenylmethoxycarbonylamino)-3-(5'-bromo-2'-pyridyl)propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / pyridine

2.1: 92 percent / NaI / acetone / 20 °C

3.1: Zn; 1,2-dibromoethane; Me₃SiCl / dimethylformamide / 2 h / 35 °C

3.2: 60 percent / Pd(PPh₃)2Cl₂ / dimethylformamide

4.1: 85 percent / aq. LiOH / tetrahydrofuran / 20 °C

With pyridine; lithium hydroxide; chloro-trimethyl-silane; ethylene dibromide; sodium iodide; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1039/b308750f