4-(3-Piperidinyl)morpholine dihydrochloride

Base Information

• Chemical Name: 4-(3-Piperidinyl)morpholine dihydrochloride
• CAS No.: 1124199-56-9
• Molecular Formula: C₉H₁₈N₂O*2ClH
• Molecular Weight: 243.177
• Hs Code.: 2934999090
• European Community (EC) Number: 819-624-7
• DSSTox Substance ID: DTXSID20696409
• Mol file: 1124199-56-9.mol

Synonyms:1124199-56-9;4-(3-PIPERIDINYL)MORPHOLINE DIHYDROCHLORIDE;4-(piperidin-3-yl)morpholine dihydrochloride;4-piperidin-3-ylmorpholine;dihydrochloride;SCHEMBL20502175;DTXSID20696409;KFISTJJMJNYLLO-UHFFFAOYSA-N;AKOS015845608;4-(piperidin-3-yl)morpholinedihydrochloride;CS-0437955;FT-0681402;4-piperidin-3-yl-morpholine, di-hydrochloride;E87024;EN300-233445;4-(Piperidin-3-yl)morpholine--hydrogen chloride (1/2);Z2234631201

Chemical Property of 4-(3-Piperidinyl)morpholine dihydrochloride

Chemical Property:

• PSA: 24.50000
• LogP: 1.94130
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 242.0952687
• Heavy Atom Count: 14
• Complexity: 135

Purity/Quality:

98%min ^*data from raw suppliers

4-(3-Piperidinyl)morpholine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)N2CCOCC2.Cl.Cl

Technology Process of 4-(3-Piperidinyl)morpholine dihydrochloride

There total 2 articles about 4-(3-Piperidinyl)morpholine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-morpholinopiperidine-1-carboxylate (1233184-27-4) → 4-(piperidin-3-yl)morpholine dihydrochloride (1124199-56-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

3-oxo-piperidine-1-carboxylic acid tert-butyl ester (98977-36-7) → 4-(piperidin-3-yl)morpholine dihydrochloride (1124199-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; acetic acid; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane;

upstream raw materials:

tert-butyl 3-morpholinopiperidine-1-carboxylate

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

Refernces