4-Nitro-2-(trifluoroMethyl)-1H-indole

Base Information

• Chemical Name: 4-Nitro-2-(trifluoroMethyl)-1H-indole
• CAS No.: 1000604-20-5
• Molecular Formula: C9H5F3N2O2
• Molecular Weight: 230.1434096
• Mol file: 1000604-20-5.mol

Synonyms:4-Nitro-2-(trifluoroMethyl)-1H-indole

Chemical Property of 4-Nitro-2-(trifluoroMethyl)-1H-indole

Chemical Property:

• PSA: 61.61000
• LogP: 3.61810
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Nitro-2-(trifluoromethyl)-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Nitro-2-(trifluoroMethyl)-1H-indole

There total 4 articles about 4-Nitro-2-(trifluoroMethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-hydroxy-4-nitro-2-(trifluoromethyl)indole (1388183-70-7) → 4-nitro-2-(trifluoromethyl)indole (1000604-20-5)

Guidance literature:

With triethylamine; α-bromoacetophenone; In methanol; at 20 ℃; for 3h;

DOI:10.1055/s-0031-1291044

Reference yield:

N-(2,6-dimethyl-3-nitrophenyl)-2,2,2-trifluoroacetimidoyl chloride (1000604-19-2) → 4-nitro-2-(trifluoromethyl)indole (1000604-20-5)

Guidance literature:

With potassium ethoxide; oxalic acid diethyl ester; In N,N-dimethyl-formamide; at 0 - 40 ℃; for 5h;

Reference yield:

1,1,1-trifluoro-3-(2,6-dinitrophenyl)propan-2-one (1388183-57-0) → 4-nitro-2-(trifluoromethyl)indole (1000604-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(ll) chloride / ethanol; ethyl acetate / 20 °C

2: triethylamine; α-bromoacetophenone / methanol / 3 h / 20 °C

With triethylamine; α-bromoacetophenone; tin(ll) chloride; In methanol; ethanol; ethyl acetate;

DOI:10.1055/s-0031-1291044

upstream raw materials:

N-(2,6-dimethyl-3-nitrophenyl)-2,2,2-trifluoroacetimidoyl chloride

1,1,1-trifluoro-3-(2,6-dinitrophenyl)propan-2-one

1-hydroxy-4-nitro-2-(trifluoromethyl)indole

2,6-dinitrotoluene

Refernces

• 1、 -. "NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF". Page/Page column 42. . Retrieved 2009/04/23.