5,7-DIFLUORO-2-INDOLECARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5,7-DIFLUORO-2-INDOLECARBOXYLIC ACID ETHYL ESTER
• CAS No.: 220679-10-7
• Molecular Formula: C11H9F2NO2
• Molecular Weight: 225.193
• Mol file: 220679-10-7.mol

Synonyms:5,7-DIFLUORO-2-INDOLECARBOXYLIC ACID ETHYL ESTER;ethyl 5,7-difluoro-1H-indole-2-carboxylate;5,7-Difluoro-1H-indole-2-carboxylic acid ethyl ester;1H-Indole-2-carboxylic acid, 5,7-difluoro-, ethyl ester

Chemical Property of 5,7-DIFLUORO-2-INDOLECARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Melting Point: 175-177℃ (ethanol )
• PSA: 42.09000
• LogP: 2.62280

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5,7-difluoro-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-DIFLUORO-2-INDOLECARBOXYLIC ACID ETHYL ESTER

There total 4 articles about 5,7-DIFLUORO-2-INDOLECARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

→ ethyl 5,7-difluoro-1H-indole-2-carboxylate (220679-10-7)

Guidance literature:

Reference yield: 15.0%

ethyl (2E)-2-[(2,4-difluorophenyl)hydrazono]propanoate → ethyl 5,7-difluoro-1H-indole-2-carboxylate (220679-10-7)

Guidance literature:

PPA; at 110 ℃; for 0.5h;

DOI:10.1021/jm070488f

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → ethyl 5,7-difluoro-1H-indole-2-carboxylate (220679-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite; sodium acetate / ethanol; water / 2 h / -5 - 0 °C

2: trifluoroacetic acid / 16 h / 100 °C

With hydrogenchloride; sodium acetate; trifluoroacetic acid; sodium nitrite; In ethanol; water;

upstream raw materials:

ethyl 2-(2-(2,4-difluorophenyl)hydrazono)propanoate

2,4-difluorophenylamine

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