ent-Ivabradine Hydrochloride

Base Information

Chemical Name:ent-Ivabradine Hydrochloride
CAS No.:148849-68-7
Molecular Formula:
Molecular Weight:505.04608
Hs Code.:
Mol file:148849-68-7.mol

Synonyms:ent-Ivabradine Hydrochloride

Suppliers and Price of ent-Ivabradine Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ent-IvabradineHydrochloride
10mg
$ 1390.00

Medical Isotopes, Inc.
ent-IvabradineHCl
5 mg
$ 650.00

Total 9 raw suppliers

Chemical Property of ent-Ivabradine Hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

ent-IvabradineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3,3''-(Propane-1,3-diyl)bis(7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one) is an impurity of 3,3''-(Propane-1,3-diyl)bis(7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one) (P760340); an impurity in the synthesis of Ivabradine (I940500) which is a selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Also antianginal.

Technology Process of ent-Ivabradine Hydrochloride

There total 45 articles about ent-Ivabradine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

: 1086026-31-4
3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

: 148849-67-6,148849-68-7
ivabradine hydrochloride

Guidance literature:: 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one; With palladium 10% on activated carbon; hydrogen; acetic acid; at 15 - 25 ℃; for 23h;

With hydrogenchloride; In ethyl acetate; isopropyl alcohol; at 0 - 10 ℃; for 1h;

Reference yield: 85.0%

: 3-(2-[1,3]-dioxolan-2-yl-ethyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one

: 866783-13-3
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

: 148849-67-6,148849-68-7
ivabradine hydrochloride

Guidance literature:: 3-(2-[1,3]-dioxolan-2-yl-ethyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one; With hydrogen; palladium on activated charcoal; In ethanol; at 55 ℃; under 3750.38 Torr;

1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride; In ethanol; water; at 20 - 85 ℃; under 22502.3 Torr;

Reference yield: 85.0%

: 866462-51-3
3-[2-(1,3-Dioxolan-2-yl)-ethyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one

: 866783-13-3
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride

: 148849-67-6,148849-68-7
ivabradine hydrochloride

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; water; at 85 ℃; under 22502.3 Torr; Autoclave;
DOI:10.1002/adsc.201601222