Benzyl 4-amino-4-methylpiperidine-1-carboxylate

Base Information

• Chemical Name: Benzyl 4-amino-4-methylpiperidine-1-carboxylate
• CAS No.: 169750-59-8
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.325
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20696080
• Wikidata: Q82625508
• Mol file: 169750-59-8.mol

Synonyms:169750-59-8;BENZYL 4-AMINO-4-METHYLPIPERIDINE-1-CARBOXYLATE;1-CBZ-4-AMINO-4-METHYLPIPERIDINE;4-Amino-4-methyl-1-N-CBZ piperidine;4-AMINO-4-METHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;SCHEMBL1709936;DTXSID20696080;MFCD03840719;AKOS024262098;PB30780;AM100349;AS-34685;CS-0022295;FT-0705717;BENZYL4-AMINO-4-METHYLPIPERIDINE-1-CARBOXYLATE

Chemical Property of Benzyl 4-amino-4-methylpiperidine-1-carboxylate

Chemical Property:

• PSA: 55.56000
• LogP: 2.77460
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 248.152477885
• Heavy Atom Count: 18
• Complexity: 280

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzyl4-Amino-4-methylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCN(CC1)C(=O)OCC2=CC=CC=C2)N

Technology Process of Benzyl 4-amino-4-methylpiperidine-1-carboxylate

There total 1 articles about Benzyl 4-amino-4-methylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ benzyl 4-amino-4-methylpiperidine-1-carboxylate (169750-59-8)

Guidance literature:

Reference yield:

benzyl 4-amino-4-methylpiperidine-1-carboxylate (169750-59-8) → 2-((3,5-dicyano-6-(4-((2,2-difluoroethyl) amino)-4-methylpiperidin-1-yl)-4-ethylpyridin-2-yl)thio)-2-phenylacetamide

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 19 h / 0 - 50 °C

2.1: palladium on activated charcoal; hydrogen / ethanol / 2 h / 1551.49 Torr

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 55 °C

4.1: ethanol; sodium tetrahydroborate / 0.17 h / 70 °C

4.2: 0.17 h / 70 °C

With sodium tetrahydroborate; ethanol; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; acetonitrile;

Refernces